Hmo1:A versatile member of the high mobility group box family of chromosomal architecture proteins  

Hmo1:A versatile member of the high mobility group box family of chromosomal architecture

作　　者：Xin Bi 

机构地区：[1]Department of Biology,University of Rochester,Rochester,NY 14627,United States

出　　处：《World Journal of Biological Chemistry》2024年第1期1-10,共10页世界生物化学杂志（英文版）（电子版）

摘　　要：Eukaryotic chromatin consisting of nucleosomes connected by linker DNA is organized into higher order structures,which is facilitated by linker histone H1.Formation of chromatin compacts and protects the genome,but also hinders DNA transactions.Cells have evolved mechanisms to modify/remodel chromatin resulting in chromatin states suitable for genome functions.The high mobility group box(HMGB)proteins are non-histone chromatin architectural factors characterized by one or more HMGB motifs that bind DNA in a sequence nonspecific fashion.They play a major role in chromatin dynamics.The Saccharomyces cerevisiae(yeast hereafter)HMGB protein Hmo1 contains two HMGB motifs.However,unlike a canonical HMGB protein that has an acidic C-terminus,Hmo1 ends with a lysine rich,basic,C-terminus,resembling linker histone H1.Hmo1 exhibits characteristics of both HMGB proteins and linker histones in its multiple functions.For instance,Hmo1 promotes transcription by RNA polymerases I and II like canonical HMGB proteins but makes chromatin more compact/stable like linker histones.Recent studies have demonstrated that Hmo1 destabilizes/disrupts nucleosome similarly as other HMGB proteins in vitro and acts to maintain a common topological architecture of genes in yeast genome.This minireview reviews the functions of Hmo1 and the underlying mechanisms,highlighting recent discoveries.

关 键 词：Hmo1 High mobility group box proteins CHROMATIN Chromatin remodeling Gene regulation Ribosomal DNA Ribosomal protein genes DNA damage response Linker histone 

分 类 号：R914[医药卫生—药物化学]