生物启发和生物工程核酸药物载体  

Bioinspired and bioengineered nucleic acid drug carriers

作　　者：左嘉敏 卢治国 郭京 赵睿琛 张田露 王朝霞 袁云 邓健文 袁俊亮 张欣 Jiamin Zuo;Zhiguo Lu;Jing Guo;Ruichen Zhao;Tianlu Zhang;Zhaoxia Wang;Yun Yuan;Jianwen Deng;Junliang Yuan;Xin Zhang(State Key Laboratory of Biochemical Engineering,Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190,China;School of Chemical Engineering,University of Chinese Academy of Sciences,Beijing 100049,China;Department of Neurology,Peking University Sixth Hospital,Peking University Institute of Mental Health,Beijing 100191,China;Department of Neurology,Peking University First Hospital,Beijing 100034,China;Beijing Key Laboratory of Neurovascular Disease Discovery,Beijing 100034,China;Key Laboratory of Biopharmaceutical Preparation and Delivery,Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190,China)

机构地区：[1]State Key Laboratory of Biochemical Engineering,Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190,China [2]School of Chemical Engineering,University of Chinese Academy of Sciences,Beijing 100049,China [3]Department of Neurology,Peking University Sixth Hospital,Peking University Institute of Mental Health,Beijing 100191,China [4]Department of Neurology,Peking University First Hospital,Beijing 100034,China [5]Beijing Key Laboratory of Neurovascular Disease Discovery,Beijing 100034,China [6]Key Laboratory of Biopharmaceutical Preparation and Delivery,Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190,China

出　　处：《Science China Materials》2024年第8期2393-2413,共21页中国科学（材料科学）（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(32225029,22205240,52073287,22075289,82071552 and 22376006);the National Key R&D Program of China(2023YFC2605003)。

摘　　要：核酸药物具有直接作用于致病基因的优势,在治疗各种疾病方面具有巨大潜力.然而,由于核酸药物需要克服多重生理障碍才能到达靶点,因此在实际应用中面临诸多困难和挑战.为了提高核酸药物的稳定性和递送效率,研究人员开始利用生物工程化和生物启发材料所具有的内源性递送生物大分子的能力来递送核酸药物.本文重点介绍核酸药物递送过程中需要克服的生物障碍,以及生物工程和生物启发材料在核酸药物递送中的优势和应用.通过利用这些先进的生物材料,研究人员有望提高核酸药物的疗效,为疾病治疗提供新的解决方案.Nucleic acid drugs have great potential in treating various diseases due to their advantage of directly acting on disease-causing genes.However,since they need to overcome multiple biological barriers to reach the target,they face many difficulties and challenges in practical applications.In order to improve the stability and delivery efficiency of nucleic acid drugs,researchers have begun to take advantage of the ability to deliver biomolecules endogenously,as possessed by bioengineered and bioinspired materials,for nucleic acid drug delivery.This paper focuses on the biological barriers that need to be overcome during the delivery of nucleic acid drugs and the advantages and applications of bioengineered and bioinspired materials in nucleic acid drug delivery.By utilizing these state-of-the-art biomaterials,researchers are expected to improve the therapeutic efficacy of nucleic acid drugs and provide a new solution for disease treatment.

关 键 词：生物工程 药物递送 生理障碍 生物启发 致病基因 生物大分子 工程化 疾病治疗 

分 类 号：Q78[生物学—分子生物学] TQ460.4[化学工程—制药化工]