New evidence for the epigenetic regulation of skeletal stem cells  

作　　者：Liming Zhao Jun Xiao Charles K.F.Chan 

机构地区：[1]Institute for Stem Cell Biology and Regenerative Medicine,Stanford University School of Medicine,Stanford CA 94305,USA [2]Department of Surgery,Division of Plastic and Reconstructive Surgery,Stanford University School of Medicine,Stanford CA 94305,USA [3]Department of Orthopaedic Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

出　　处：《Science Bulletin》2024年第13期2004-2006,共3页科学通报（英文版）

基　　金：supported by the National Institutes of Health(K99-R00AG049958 and S10OD028493);the American Heart Association(24POST1188725);the Heritage Medical Foundation,the Wu Tsai Human Performance Alliance,the Arthritis National Research Foundation,and the American Federation for Aging Research.

摘　　要：Skeletal stem cells(SSCs)are crucial for skeletal development and regeneration,yet the epigenetic regulation of these cells remains poorly understood.Recent studies have delineated the epigenetic landscape across the developmental trajectory of SSCs,highlighting the involvement of Ptip in regulating SSC activity.The skeletal system undergoes dynamic remodeling throughout life.Skeletal stem cells(SSCs),residing within the skeleton and lineage-restricted,serve as a cellular reserve to foster development and maintain skeletal homeostasis.Historically categorized within the broader mesenchymal stromal/stem cells(MSCs).

关 键 词：SKELETAL INVOLVEMENT MAINTAIN 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]