滇重楼内生真菌Penicillium chrysogenum次生代谢产物研究  

Secondary metabolites of endophytic fungus Penicillium chrysogenum derived from Paris polyohylavar.Yunnanensis

作　　者：何开香 陆小凯 杨海英[1] 胡琳[1] 杜刚[1] 蒋孟圆[1] HE Kai-xiang;LU Xiao-kai;YANG Hai-ying;HU Lin;DU Gang;JIANG Meng-yuan(Key Lab of Ethnic Medicine Resource Chemistry,State Ethnic Affairs Commission&Ministry of Education,Yunnan MinZu University,Kunming 650500,China)

机构地区：[1]云南民族大学民族药资源化学国家民族事务委员会-教育部重点实验室,云南昆明650500

出　　处：《云南民族大学学报（自然科学版）》2024年第4期417-421,共5页Journal of Yunnan Minzu University:Natural Sciences Edition

基　　金：国家自然科学基金(81903519,81860624).

摘　　要：运用多种色谱分离方法对滇重楼内生真菌Penicillium chrysogenum YNCA1212次生代谢产物进行化学成分研究,共分离鉴定了9个化合物,分别为:macrophorin A(1)、macrophorin D(2)、peniginsengin A(3)、dihydrodemethylsorbicillin(4)、2′,3′-dihydrosorbicillin(5)、(2E,4E)-1-(2,6-dihydroxy-3,5-dimethyl-phenyl)hexa-2,4-dien-1-one(6)、(S)-penipratynolene(7)、3,5-dihydroxytoluene(8)、N-(2-hydroxypropanoyl)-2-aminobenzoic acid amide(9),化合物6对金黄色葡萄球菌具有弱的抑菌活性(IC 50=136.7μg/mL).Nine compounds were isolated from endophytic fungus Penicillium chrysogenum YNCA1212 derived from Paris polyohylavar.Yunnanensis by chromatographic methods.Their structures were elucidated as macrophorin A(1),macrophorin D(2),peniginsengin A(3),dihydrodemethylsorbicillin(4),2′,3′-dihydrosorbicillin(5),(2E,4E)-1-(2,6-dihydroxy-3,5-dimethyl-phenyl)hexa-2,4-dien-1-one(6),(S)-penipratynolene(7),3,5-dihydroxytoluene(8),N-(2-hydroxypropanoyl)-2-aminobenzoic acid amide(9).Compound 6 showed weak antimicrobial activity against Staphylococcus aureus(IC 50=136.7μg/mL).

关 键 词：内生真菌 产黄青霉菌 滇重楼 杂萜 化学成分 

分 类 号：Q936[生物学—微生物学]