Modulating the crosstalk between macrophage and Th17: potential mechanism of natural products on acute lung injury  

作　　者：Xi-Xing Fang Han-Zhou Li Ning Wang Wen-Ju He Yu-Lin Wu Li-Ying Guo Li-Wei Xing Wei-Bo Wen Qian-Qian Wan Huan-Tian Cui 

机构地区：[1]Medical School,Hubei Minzu University,Enshi 445099,China [2]College of Integrative Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China [3]First School of Clinical Medicine,Yunnan University of Chinese Medicine,Kunming 650500,China [4]Department of Critical Care Medicine,Tianjin First Central Hospital,Tianjin 300192,China [5]National Clinical Research Center for Cancer,Tianjin Medical University Cancer Institute&Hospital,Tianjin 300060,China [6]Department of Hepatology,Tianjin Second People's Hospital,Tianjin 300193,China [7]Medical Affairs Department,The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine,Kunming 650021,China.

出　　处：《Biomedical Engineering Communications》2024年第3期31-37,共7页生物医学工程通讯

基　　金：supported by the National Natural Science Foundation of China(No.82104581,No.82060864).

摘　　要：Sepsis is a life-threatening multiple organ dysfunction syndrome caused by the imbalance of the immune response to infection,featuring complex and variable conditions,and is one of the leading causes of mortality in ICU patients.Lung injury is a common organ damage observed in sepsis patients.Macrophages and Th17 cells,as crucial components of innate and adaptive immunity,play pivotal roles in the development of sepsis-induced acute lung injury(ALI).This review summarizes the alterations and mechanisms of macrophages and Th17 cells in sepsis-induced ALI.By focusing on the“cross-talk”between macrophages and Th17 cells,this review aims to provide a solid theoretical foundation for further exploring the therapeutic targets of traditional Chinese medicine formulas in the treatment of sepsis complicated with ALI,thereby offering insights and guidance for the clinical application of traditional Chinese medicine in managing sepsis-associated ALI.

关 键 词：sepsis-induced acute lung injury MACROPHAGES Th17 cells traditional Chinese medicine 

分 类 号：R57[医药卫生—消化系统]