Bioactive components,pharmacological properties and underlying mechanism of Ganoderma lucidum spore oil:A review  

作　　者：Jianying Liu Binzhi Zhang Leqi Wang Shasha Li Qinqiang Long Xue Xiao 

机构地区：[1]Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine(Institute of Chinese Medicine),Guangdong Pharmaceutical University,Guangzhou 510006,China [2]The Second Clinical College of Guangzhou University of Chinese Medicine,Guangzhou Higher Education Mega Center,Guangzhou 510120,China [3]NMPA Key Laboratory for Rapid Testing Technology of Drugs,Guangdong Institute for Drug Control,Guangzhou 510525,China

出　　处：《Chinese Herbal Medicines》2024年第3期375-391,共17页中草药（英文版）

基　　金：supported by Pearl River S&T Nova Program of Guangzhou(No.201610010113);the Open Research Fund of NMPA Key Laboratory for Rapid Testing Technology of Drugs,Guangdong Institute for Drug Control(No.KF2022002,KF2022006);Research Project of Chinese Medicine in TCM Bureau of Guangdong Province(No.20231202).

摘　　要：Ganoderma lucidum is a Chinese medicinal fungus with a long history of use in healthcare and disease treatment.G.lucidum spores(GLS)are tiny germ cells released from the mushroom cap during the mature stage of growth.They contain all the genetic active substances of G.lucidum.G.lucidum spore oil(GLSO)is a lipid component extracted from broken-walled Ganoderma spores using supercritical CO_(2)extraction technology.GLSO contains fatty acids,Ganoderma triterpenes,sterols and other bioactive compounds.Previous studies have demonstrated that GLSO has a wide range of pharmacological properties,including anti-tumor,anti-aging,neuroprotection,immunomodulation,hepatoprotection and modulation of metabolic diseases.This review summarizes the research progress of GLSO over the past two decades in terms of its bioactive components,extraction and processing techniques,pharmacological effects and safety evaluation.This provides a solid foundation for further research and application of GLSO.

关 键 词：ANTI-AGING ANTI-TUMOR bioactive components Ganoderma lucidum spore oil HEPATOPROTECTION immune regulation pharmacological properties 

分 类 号：R284.1[医药卫生—中药学] R285[医药卫生—中医学]