Research p rogress on Chinese herbal drugs in the TGF- β signaling pathway involved in epithelial-mesenchymal transition  

作　　者：Hui-Juan Cao Chen-Xi Wu Xiao-Le Xian Yong-Sen Jia Yue-Yue Yu Shu Zhao Ting-Ting Fu 

机构地区：[1]Traditional Chinese Medicine College,North China University of Science and Technology,Tangshan 063210,China.

出　　处：《Cancer Advances》2024年第17期1-12,共12页TMR肿瘤进展

基　　金：supported by the Science and Technology Project of Hebei Education Department(QN2018060);Hebei Natural Science Foundation(H2022209027);Tangshan Science and Technology Project(21130230C)and Tangshan Talent Funding Project(A202203021);the Central Government Guides Local Funds For Science a nd Technology Development(Free Exploration o f Basic Research):the synergistic effect of nuclear targeted PTX/CUR nanodelivery system combined photothermal/photodynamic on breast cancer(236Z2704G);Natural Science Foundation of Hebei Province(H2022209068).

摘　　要：Epithelial-mesenchymal transition is a well-defined,reversible process in which epithelial cells lose their epithelial phenotype and acquire mesenchymal-like features.Epithelial-mesenchymal transition contributes significantly to the metastasis,invasion,and development of treatment resistance in cancer cells.There have been many studies on suppression of tumor epithelial-mesenchymal transition by Chinese medicine in recent years,mainly based on Chinese herbal drug monomers and compounds.In this review,we aim to describe the research progress on Chinese medicine in the t ransforming growth factor beta(T GF-β)sig naling pathway,we hope these will provide some guidance for further research on Chinese medicine targeting epithelial-mesenchymal transition.

关 键 词：epithelial-mesenchymal transition cancer Chinese medicine INVASION METASTASIS 

分 类 号：R73[医药卫生—肿瘤]