The pathogenesis of Parkinson’s disease and crosstalk with other diseases  

作　　者：TINGTING LIU DINGYOU GUO JIANSHE WEI 

机构地区：[1]Institute for Brain Sciences Research,School of Life Sciences,Henan University,Kaifeng,475004,China

出　　处：《BIOCELL》2024年第8期1155-1179,共25页生物细胞（英文）

基　　金：supported partly by the National Natural Science Foundation of China(32161143021,81271410);Henan University Graduate《Talent Program》of Henan Province(SYLYC2023092);Henan Natural Science Foundation of China(182300410313).

摘　　要：In China,Parkinson’s disease(PD)is the second most prevalent central nervous system(CNS)degenerative illness affecting middle-aged and older persons.Movement disorders including resting tremor,bradykinesia,myotonia,postural instability,and gait instability are the predominant clinical symptoms.The two main types of PD are sporadic and familial,with sporadic PD being the more prevalent of the two.The environment,genetics,mitochondrial dysfunction,oxidative stress,inflammation,protein aggregation and misfolding,loss of trophic factors,cell death,and gut microbiota may all have a role in the etiology of PD.PD is inversely connected with other cancers and positively correlated with COVID-19,diabetes mellitus(DM),melanoma,and ischemic heart disease(IHD)risk.Delaying disease progression,managing motor and non-motor symptoms,and avoiding and controlling dysfunction in the middle and later phases of the disease are the key areas of research and development for its therapy.Presently,the development and progression of PD can be slowed down by using conventional pharmacology,natural items,and innovative technology.This article reviews the pathogenesis of PD,its correlations with other non-genetic diseases,and the research progress of drugs and technologies for alleviating PD.

关 键 词：Parkinson’s disease Mitochondrial dysfunction Oxidative stress Inflammation Cancer THERAPIES 

分 类 号：R742.5[医药卫生—神经病学与精神病学]