Neg-Entropy Mechanism as a Target for Natural Medicines  

作　　者：Tian-Le Gao Hui-Hui Guo Jian-Dong Jiang 

机构地区：[1]Institute of Materia Medica,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100050,China [2]Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100050,China

出　　处：《Engineering》2024年第7期11-12,共2页工程（英文）

基　　金：supported by the Major Consulting Project of the Chinese Academy of Engineering(2023-XZ-88).

摘　　要：Current strategies for drug discovery research mainly focus on molecular targets,in which structure biology plays a central role,such as the detailed mechanism of a drug-target interaction.The principle of this approach is the presumed molecular mechanism or genetic background of the disease being treated.Although this approach has brought progress in understanding the mode of action for some drugs,most prevalent illnesses-especially chronic diseases-are multifactorial and present with a group of symptoms,as is often the case in cardiovascular diseases,metabolic disorders,cancers,and so forth.The newly emerging term“multi-morbidity”(i.e.,multiple co-occurring diseases)describes a grand challenge for this strategy,and successful drug intervention for multimorbidity should be multifaceted[1].So,our research team has shifted its attention to a new direction that views the disease as a whole instead of a single-molecule abnormality,and focusing on drugs with multiple targets.

关 键 词：DRUGS DISEASES CARDIOVASCULAR 

分 类 号：R91[医药卫生—药学]