甲状腺未分化癌的靶向治疗进展  

Progress of Targeted Therapy for Anaplastic Thyroid Cancer

作　　者：殷德涛[1,2] 刘维豪 YIN Detao;LIU Weihao(Department of Thyroid Surgery,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Key Medicine Laboratory of Thyroid Cancer of Henan Province,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院甲状腺外科,郑州450052 [2]河南省甲状腺癌医学重点实验室,郑州450052

出　　处：《肿瘤防治研究》2024年第8期617-624,共8页Cancer Research on Prevention and Treatment

基　　金：河南省自然科学基金面上项目(222300420568);河南省医学科技攻关重大计划项目(SBGJ202101014);河南省中医药研究河南省中青年医学重大专项(20-21ZYZD14);河南省中青年医学科技创新领军人才项目(YXKC2020015)。

摘　　要：甲状腺未分化癌是一种极其罕见的甲状腺恶性肿瘤,因其侵袭性强、预后差,是目前甲状腺癌的主要致死原因。甲状腺未分化癌的手术难度通常较大,且传统放化疗的意义不够明确,而靶向治疗的出现彻底改变了传统的肿瘤治疗模式。靶向治疗通过特异性作用于肿瘤相关的特定分子和信号通路来实现抗肿瘤效应。与传统化疗相比,靶向治疗可以更精确地攻击肿瘤细胞,并减少对正常细胞的损伤。随着靶向治疗临床试验的深入,发现应用靶向药物治疗对提高甲状腺未分化癌患者总生存期有明显效果,靶向治疗以及肿瘤相关信号通路逐渐成为甲状腺未分化癌治疗的研究热点之一。本文结合现阶段靶向药物在甲状腺未分化癌治疗方面的研究,对甲状腺未分化癌靶向治疗的进展作一综述。Anaplastic thyroid cancer,an extremely rare malignant tumor of the thyroid gland,is a major cause of mortality in thyroid cancer because of its aggressiveness and poor prognosis.Anaplastic thyroid cancer is typically challenging to treat surgically,and the efficacy of traditional radiotherapy and chemotherapy remains unclear.Meanwhile,the emergence of targeted therapy has radically transformed the traditional mode of tumor treatment.Anti-tumor effects can be achieved by specifically targeting tumor-associated molecules and signaling pathways.Compared with conventional chemotherapy,targeted therapy is able to more precisely target tumor cells while minimizing damage to normal cells.With the advancement of clinical trials on targeted therapy,the use of targeted drugs has been observed to significantly improve overall survival of patients with anaplastic thyroid cancer.Targeted therapy and tumor-related signaling pathways have emerged as research hotspots in the treatment of anaplastic thyroid cancer.This article offers an overview of the progress of targeted therapy for anaplastic thyroid cancer,incorporating current research on targeted drugs in the treatment of this condition.

关 键 词：甲状腺未分化癌 靶向治疗 信号通路 基因突变 

分 类 号：R736.1[医药卫生—肿瘤]