表没食子儿茶素没食子酸酯预防并改善非酒精性脂肪性肝病的作用机制及研究进展  

The Mechanism and Research Progress of Epigallocatechin Gallate in Improving Non-alcoholic Fatty Liver Disease

作　　者：陈佳欣 张锦佳 左会灵 焦宇航 石安华 CHEN Jiaxin;ZHANG Jinjia;ZUO Huiling;JIAO Yuhang;SHI Anhua(Yunnan University of Chinese Medicine,Kunming 650500,China;Key Laboratory of Microcosmic Syndrome Differentiation for TCM Syndromes in Universities of Yunnan Province,Kunming 650500,China)

机构地区：[1]云南中医药大学基础医学院,云南昆明650500 [2]云南省高校中医证候微观辨证重点实验室,云南昆明650500

出　　处：《茶叶科学》2024年第4期543-553,共11页Journal of Tea Science

基　　金：国家自然科学基金(82360863)、云南省科学技术厅中医联合专项-重点项目(202001AZ070001-005)。

摘　　要：非酒精性脂肪性肝病(Nonalcoholic fatty liver disease,NAFLD)发病率逐年升高,目前尚无特效药物。绿茶的有效成分表没食子儿茶素没食子酸酯(Epigallocatechin gallate,EGCG)在低剂量范围内已被证明对NAFLD具有良好的改善作用。综述总结了EGCG通过抗氧化应激、抗炎、抑制铁死亡、减少脂质生成、调节自噬、调节肠道菌群以及降低胆汁酸代谢等方面延缓NAFLD发生发展的部分机制,以期为改善NAFLD的深入研究提供启示。The incidence of nonalcoholic fatty liver disease(NAFLD)is increasing year by year and there is no specific drug available.The active ingredient of green tea,epigallocatechin gallate(EGCG),has been widely proven to have a favorable ameliorative effect on NAFLD in the low dose range.Some of the mechanisms by which EGCG delays the development of NAFLD through anti-oxidative stress,anti-inflammation,inhibition of iron death,reduction of lipogenesis,up-regulation of autophagy,modulation of intestinal flora,and reduction of bile acid metabolism were summarized in this paper,so as to provide insights for in-depth research on improving NAFLD.

关 键 词：非酒精性脂肪性肝病 表没食子儿茶素没食子酸酯 氧化应激 炎症 

分 类 号：S571.1[农业科学—茶叶生产加工] R575.5[农业科学—作物学]