Circadian rhythm dysfunction and psychopathology in the offspring of parents with bipolar disorder:a highrisk study in the Chinese population  

作　　者：Binbin Lei Hongliang Feng Lulu Yang Jing Wang Jie Chen Weidong Song Chao Jiang Kun Zhang Qunfeng Wang Jessie Chi Ching Tsang Ngan Yin Chan Yaping Liu Joey W.Y.Chan Jiyang Pan Bin Zhang Tao Li Kathleen Ries Merikangas Jihui Zhang Yun Kwok Wing 

机构地区：[1]Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou,Guangdong,China [2]Guangdong Mental Health Center,Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences),Southern Medical University,Guangzhou,Guangdong,China [3]Li Chiu Kong Family Sleep Assessment Unit,Department of Psychiatry,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong,China [4]Center for Sleep and Circadian Medicine,The Affiliated Brain Hospital of Guangzhou Medical University,Guangzhou,Guangdong,China [5]Department of Psychiatry,Faculty of Medicine,The Chinese University of Hong Kong,New Territories,Hong Kong,China [6]Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China,Guangzhou Medical University,Guangzhou,Guangdong,China [7]Shenzhen Nanshan Center for Chronic Diseases Control(Shenzhen Nanshan Mental Health Center),Shenzhen,China [8]Department of Clinical Psychology,Shenzhen Fuyong People's Hospital,Shenzhen,China [9]Department of Mental Illness Prevention and Treatment,Shenzhen Longgang Center for Chronic Diseases Control,Shenzhen,China [10]Department of Neurology,Zhongnan Hospital of Wuhan University,Wuhan,Hubei,China [11]Sleep Medical Center,The First Affiliated Hospital of Jinan University,Guangzhou,Guangdong,China [12]Department of Psychiatry,Nanfang Hospital,Southern Medical University,Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence,Guangzhou,Guangdong,China [13]Department of Neurobiology,Affiliated Mental Health Center&Hangzhou Seventh People's Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang,China [14]Genetic Epidemiology Research Branch,Intramural Research Program,National Institute of Mental Health,Bethesda,Maryland,USA

出　　处：《General Psychiatry》2024年第3期388-400,共13页综合精神医学（英文）

基　　金：supported by the Health and Medical Research Fund of the Food and Health Bureau of Hong Kong(03140636)and the donation fund from Mr Yip WT and Mrs Yip。

摘　　要：Background Understanding the evolution of circadian rhythm dysfunction and psychopathology in the high-risk population has important implications for the prevention of bipolar disorder.Nevertheless,some of the previous studies on the emergence of psychopathologies and circadian dysfunction among high-risk populations were inconsistent and limited.Aims To examine the prevalence rates of sleep and circadian dysfunctions,mental disorders and their symptoms in the offspring of parents with(O-BD)and without bipolar disorder(O-control).Methods The study included 191 O-BD and 202 O-control subjects aged 6-21 years from the Greater Bay Area,China.The diagnoses and symptoms of sleep/circadian rhythm and mental disorders were assessed by the Diagnostic Interview for Sleep Patterns and Disorders,and the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version,respectively.Generalised estimating equations and shared frailty proportional hazards models of survival analysis were applied to compare the outcomes in the offspring.Results Adjusting for age,sex and region of recruitment,there was a significantly higher risk of delayed sleep phase symptoms(9.55%vs 2.58%,adjusted OR:4.04)in O-BD than in O-control.O-BD had a nearly fivefold higher risk of mood disorders(11.70%vs 3.47%,adjusted OR:4.68)and social anxiety(6.28%vs 1.49%,adjusted OR:4.70),a fourfold higher risk of depressive disorders(11.17%vs 3.47%,adjusted OR:3.99)and a threefold higher risk of mood symptoms(20.74%vs 10.40%,adjusted OR:2.59)than O-control.Subgroup analysis revealed that O-BD children(aged under 12 years)had a nearly 2-fold higher risk of any mental and behavioural symptoms than O-control,while there was a nearly 4-fold higher risk of delayed sleep phase symptoms,a 7.5-fold higher risk of social anxiety and a 3-fold higher risk of mood symptoms in O-BD adolescents(aged 12 years and over).Conclusions There was an increase in delayed sleep phase symptoms in O-BD adolescents compared with their control counterp

关 键 词：PREVENTION DYSFUNCTION BIPOLAR 

分 类 号：R749.4[医药卫生—神经病学与精神病学]