高脂饮食对阿尔茨海默病病变的影响及小胶质细胞在其中的作用  

Effects of high-fat diet on pathology of Alzheimer disease and role of microglia in this process

作　　者：任晶 谭超杰 邹文奇 刘静颐 盛瑜[1] REN Jing;TAN Chaojie;ZOU Wenqi;LIU Jingyi;SHENG Yu(School of Pharmacy,Beihua University,Jilin 132013,China)

机构地区：[1]北华大学药学院,吉林吉林132013

出　　处：《中国病理生理杂志》2024年第8期1542-1547,共6页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金青年基金项目资助(No.82004067);吉林省中医药科技项目资助(No.2022080)。

摘　　要：阿尔茨海默病(Alzheimer disease,AD)病程漫长,本文从AD经典病理事件时间线出发,以小胶质细胞异常激活为桥梁,以期明确AD病理事件出现时间的先后顺序。脂质代谢异常与小胶质细胞功能异常、AD病理改变密切相关,以此为介入点,本文综述了短、长期高脂饮食对AD病变发展的影响及其可能的机制,以期为AD的早期介入提供思路。Due to the long pathological process of Alzheimer disease(AD),this paper begins with the timeline of classical pathological events in AD and uses anomalous microglia activation as a starting point to elucidate the role of abnormal lipid metabolism in the pathological process of AD.This includes its influence on microglial pathology and its interactions with the two primary nodes of AD,namely,Amyloid-βand the microtubule-associated protein tau.Using this as a foundation,the paper briefly describes the effects of abnormal lipid metabolism caused by short-term and long-term high-fat diets on the pathological progression of AD and its potential mechanisms,aiming to provide a reference framework for the early intervention of AD.

关 键 词：阿尔茨海默病 高脂饮食 小胶质细胞 脂质代谢 

分 类 号：R742[医药卫生—神经病学与精神病学] Q421[医药卫生—临床医学] R589.2[生物学—神经生物学]