COX-2 blocking therapy in cisplatin chemosensitization of ovarian cancer:An allicin-based nanomedicine approach  

作　　者：Huijiao Fu Peiqin Liang Qianwen Chen Yan Wang Guang Li Xuzi Cai Shengtao Wang Kun Chen Shengying Shi Zhiqiang Yu Xuefeng Wang 

机构地区：[1]Department of Obstetrics and Gynecology,The Third Affiliated Hospital of Southern Medical University,Guangzhou 510630,China [2]Department of Obstetrics and Gynecology,Huizhou Central People’s Hospital,Huizhou 516001,China [3]Affiliated Foshan Maternity&Child Healthcare Hospital,Southern Medical University(Foshan Maternity&Child Healthcare Hospital),Foshan 528000,China [4]Guangdong Key Laboratory of New Drug Screening,School of Pharmaceutical Sciences,Southern Medical University,Guangzhou 510515,China [5]Department of Nursing,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China [6]Department of Laboratory Medicine,Dongguan Institute of Clinical Cancer Research,The Tenth Affiliated Hospital of Southern Medical University(Dongguan People’s Hospital),Dongguan 523018,China

出　　处：《Chinese Chemical Letters》2024年第8期449-454,共6页中国化学快报（英文版）

基　　金：supported by the Guangdong Basic and Applied Basic Research Foundation of China(No.2021A1515011050);President Foundation of the Third Affiliated Hospital of Southern Medical University(No.YM202202);the Health Economics Association Research Program of Guangdong Province(No.2022-WJZD-20);the Higher Education Teaching Management Association Curriculum Thinking and Administration Program of Guangdong Province(No.X-KCSZ2021082).

摘　　要：Recently,the utilization of nonsteroidal anti-inflammatory drugs(NSAIDs)to sensitize cisplatin(CDDP)has gained substantial traction in the treatment of ovarian cancer(OC).However,even widely employed NSAIDs such as celecoxib and naproxen carry an elevated risk of cardiovascular events,notably throm-bosis.Furthermore,the diminished sensitivity to CDDP therapy in OC is multifactorial,rendering the ap-plication of NSAIDs only partially effective due to their cyclooxygenase-2(COX-2)inhibiting mechanism.Hence,in this study,reactive oxygen species(ROS)-responsive composite nano-hydrangeas loaded with the Chinese medicine small molecule allicin and platinum(IV)prodrug(DTP@AP NPs)were prepared to achieve comprehensive chemosensitization.On one front,allicin achieved COX-2 blocking therapy,en-compassing the inhibition of proliferation,angiogenesis and endothelial mesenchymal transition(EMT),thereby mitigating the adverse impacts of CDDP chemotherapy.Simultaneously,synergistic chemosensi-tization was achieved from multifaceted mechanisms by decreasing CDDP inactivation,damaging mito-chondria and inhibiting DNA repair.In essence,these findings provided an optimized approach for syner-gizing CDDP with COX-2 inhibitors,offering a promising avenue for enhancing OC treatment outcomes.

关 键 词：COX-2 blocking therapy CDDP CHEMOSENSITIZATION ALLICIN Ovarian cancer 

分 类 号：R737.31[医药卫生—肿瘤] TQ460.1[医药卫生—临床医学] TB383.1[化学工程—制药化工]