CHEMOSENSITIZATION

作品数：16被引量：49H指数：4
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A natural compound-empowered podophyllotoxin prodrug nanoassembly magnifies efficacy-toxicity benefits in cancer chemotherapy
《Asian Journal of Pharmaceutical Sciences》2024年第4期103-114,共12页Ziqi Lin Yuequan Wang Wenwen Li Fei Sun Qingzhi Lv Shenwu Zhang Xiaohong Liu Feng Qin Cong Luo 
supported by the Basic Research Projects of Liaoning Provincial Department of Education(LJKZZ20220109);the Shenyang Youth Science and Technology Innovation Talents Program(No.RC210452);the National Natural Science Foundation of China(No.82204317);the Natural Science Foundation of Liaoning Province(No.2022-BS-162).
Small-molecule prodrug nanoassembly technology with a unique advantage in off-target toxicity reduction has been widely used for antitumor drug delivery.However,prodrug activation remains a rate-limiting step for exer...
关键词：Podophyllotoxin PRODRUG CHEMOSENSITIZATION Hybrid nanoassembly Cancer chemotherapy 
COX-2 blocking therapy in cisplatin chemosensitization of ovarian cancer:An allicin-based nanomedicine approach
《Chinese Chemical Letters》2024年第8期449-454,共6页Huijiao Fu Peiqin Liang Qianwen Chen Yan Wang Guang Li Xuzi Cai Shengtao Wang Kun Chen Shengying Shi Zhiqiang Yu Xuefeng Wang 
supported by the Guangdong Basic and Applied Basic Research Foundation of China(No.2021A1515011050);President Foundation of the Third Affiliated Hospital of Southern Medical University(No.YM202202);the Health Economics Association Research Program of Guangdong Province(No.2022-WJZD-20);the Higher Education Teaching Management Association Curriculum Thinking and Administration Program of Guangdong Province(No.X-KCSZ2021082).
Recently,the utilization of nonsteroidal anti-inflammatory drugs(NSAIDs)to sensitize cisplatin(CDDP)has gained substantial traction in the treatment of ovarian cancer(OC).However,even widely employed NSAIDs such as ce...
关键词：COX-2 blocking therapy CDDP CHEMOSENSITIZATION ALLICIN Ovarian cancer 
Chemosensitizing Effect of Monk Fruit Extract on Human Bladder Cancer Cells
《Journal of Cancer Therapy》2024年第6期250-264,共15页Sensuke Konno Jonathan Wong Andrew Penunuri Kelvin Zheng Muhammad Choudhury 
The outcomes of chemotherapy have been unsatisfactory with the palpable side effects. We hypothesized that natural products might help improve chemotherapy with few side effects. Recently, we came across the bioactive...
关键词：Monk Fruit ANTICANCER Bladder Cancer CHEMOSENSITIZATION Lakanto 
DNA-PK inhibition by M3814 enhances chemosensitivity in non-small cell lung cancer被引量：2
《Acta Pharmaceutica Sinica B》2021年第12期3935-3949,共15页Manni Wang Siyuan Chen Yuquan Wei Xiawei Wei 
supported by the National Natural Science Foundation Regional Innovation and Development (U19A2003, China);by the Excellent Youth Foundation of Sichuan Scientific Committee Grant in China (No. 2019JDJQ008)。
A significant proportion of non-small cell lung cancer(NSCLC) patients experience accumulating chemotherapy-related adverse events,motivating the design of chemosensitizating strategies.The main cytotoxic damage induc...
关键词：M3814 PACLITAXEL ETOPOSIDE DNA-dependent protein kinase Non-small cell lung cancer DNA repair Cell senescence CHEMOSENSITIZATION 
Shuyu pills inhibit immune escape and enhance chemosensitization in hepatocellular carcinoma被引量：6
《World Journal of Gastrointestinal Oncology》2021年第11期1725-1740,共16页Zhe Deng Yong-Jie Teng Qing Zhou Zhao-Guang Ouyang Yu-Xing Hu Hong-Ping Long Mei-Jie Hu Si Mei Feng-Xia Lin Xin-Jun Dai Bo-Yu Zhang Ting Feng Xue-Fei Tian 
Supported by National Natural Science Foundation of China,No.U20A20408,and No.82074450;Special Natural Science Fund for the Construction of an Innovative Province in Hunan Province,No.S2020JJMSXM1250;the Natural Science Foundation of Hunan Province,No.2020JJ4066;Hunan Province"domestic first-class cultivation discipline"Integrated Traditional Chinese and Western medicine open fund project,No.2018ZXYJH28 and No.2020ZXYJH35.
BACKGROUND Hepatocellular carcinoma(HCC)is characterized by dysregulation of the immune microenvironment and the development of chemoresistance.Specifically,expression of the programmed cell death protein 1(PD-1)/prog...
关键词：Shuyu pills Hepatocellular carcinoma Tumour microenvironment Immune escape CHEMORESISTANCE 
Environmentally responsive dual-targeting nanotheranostics for overcoming cancer multidrug resistance被引量：4
《Science Bulletin》2019年第10期705-714,共10页Caixia Yang Xin Pang Weihai Chen Xiaoyong Wang Gan Lin Chengchao Chu Xianzheng Zhang Xianming Deng Xiaoyuan Chen Gang Liu 
supported by the National Basic Research Development Program of China(2017YFA0205201 and 2018YFA0107301);the National Natural Science Foundation of China(81422023,81871404,81603015,U1705281,and U1505221);the Fundamental Research Funds for the Central Universities(20720160065,and 20720150141);the Program for New Century Excellent Talents in University,China(NCET-13-0502)
The development of multiple drug resistance(MDR) to chemotherapy and subsequent treatment failures are major obstacles in cancer therapy. An attractive option for combating MDR is inhibiting the expression of P-glycop...
关键词：CANCER CHEMOSENSITIZATION MULTIDRUG resistance P-GLYCOPROTEIN PH-RESPONSIVE Magnetic resonance imaging 
In vitro antitumor efficacy of Kochia indica extract on human hepatocellular carcinoma cell line with or without 5-fluorouracil
《Hepatoma Research》2017年第7期149-155,共7页Nabil Mohie Abdel-Hamid Ghada A.Tabl Yousry EEl-Bolkiny Walaa O.Zeina 
Aim: Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and the sixth most common cancer worldwide. The resistance to chemotherapy is a major obstacle in the treatment of HCC, necessitating the...
关键词：HEPATOCELLULAR carcinoma Kochia INDICA 5-FLUOROURACIL cells of HEPATOMA cell line CHEMOSENSITIZATION 
Shenmai injection enhances the cytotoxicity of chemotherapeutic drugs against colorectal cancers via improving their subcellular distribution被引量：26
《Acta Pharmacologica Sinica》2017年第2期264-276,共13页Wen-yue LIU Jing-wei ZHANG Xue-quanYAO Chao JIANG Ji-chao HE Pin NI Jia-li LIU Qian-ying CHEN Qing-ran LI Xiao-jie ZANG Lan YAO Ya-zhong LIU Mu-lan WANG Pei-qiang SHEN Guang-ji WANG Fang ZHOU 
Shenmai injection （SMI） is a Chinese patent-protected injection, which was mainly made of Red Ginseng and Radix Ophiopogonis and widely used for treating coronary heart disease and tumors by boosting Qi and nourishi...
关键词：traditional Chinese medicine Shenmai injection colorectal cancers ADRIAMYCIN PACLITAXEL CHEMOSENSITIZATION PHARMACOKINETICS P-GLYCOPROTEIN 
Chemosensitization of HepG2 cells by suppression of NF-κB/p65 gene transcription with specific-si RNA被引量：5
《World Journal of Gastroenterology》2015年第45期12814-12821,共8页Yun Shi Si-Ye Wang Min Yao Wen-Li Sai Wei Wu Jun-Ling Yang Yin Cai Wen-Jie Zheng Deng-Fu Yao 
Supported by Grants from the Jiangsu Provincial Special Programs of Medical Science;BL2012053;HK201102;the Nantong Undertaking and Technological Innovation;HS2013007;BK2013048 and HS2014078;the Priority Academic Program Development of Higher Education Institution of Jiangsu Province;the National Natural Science Foundation;No.81200634;the international S&T Cooperation Program(2013DFA32150)of China
AIM: To investigate small interfering RNA(si RNA)-mediated inhibition of nuclear factor-kappa B(NF-κB) activation and multidrug-resistant(MDR) phenotype formation in human Hep G2 cells. METHODS: Total RNA was extract...
关键词：HEPATOCELLULAR CARCINOMA Nuclear factorκB Multidru 
Influence of Tamoxifen or the combination of Tamoxifen and Cisplatin on the growth of human lung adenocarcinoma A549 cells被引量：1
《The Chinese-German Journal of Clinical Oncology》2014年第11期523-527,共5页Yuxuan Che Xiuhua Sun Chaomei Huang Jinbo Zhao 
Supported by a grant of Project fund of Science Department of Liaoning Province(No.2009225009-5)
The experiment aims to investigate the influence of Tamoxifen and the combination of Tamoxifen and Cisplatin （DDP） on the growth of human lung adenocarcinoma A549 cells. Methods： We treated human lung adenocarcinom...
关键词：TAMOXIFEN Cisplatin （DDP） CHEMOSENSITIZATION A549 cells 
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