磁共振扩散张量成像在青少年抑郁症中的研究进展  

Advances in Magnetic Resonance Diffusion Tensor Imaging of Adolescent Depression

作　　者：邓杰 邱丽华 DENG Jie;QIU Lihua(Department of Radiology,the Affiliated Hospital of Southwest Medical University,Luzhou 646000,China;Clinical Medicine Research and Transformation Center of Yibin Hospital of the Second People's Hospital of Yibin City·West China Hospital of Sichuan University,Neuroimaging Big Data Research Center,Yibin 644000,China)

机构地区：[1]宜宾市第四人民医院放射科,四川宜宾644000 [2]西南医科大学附属医院放射科,四川泸州646000 [3]宜宾市第二人民医院·四川大学华西医院宜宾医院临床医学研究与转化中心,神经影像大数据研究中心,四川宜宾644000

出　　处：《中国医学影像学杂志》2024年第8期850-854,共5页Chinese Journal of Medical Imaging

基　　金：四川省科技计划项目(2018JY0666);中国博士后科学基金第58批(2015M582554);四川省卫生和计划生育委员会科研课题(150251);功能与分子影像四川省重点实验室开放课题(SCU-HM-2021001);宜宾市卫生健康委员会项目(2020YW085);成都中医药大学“杏林学者”课题(YYZX2020111)。

摘　　要：抑郁症是致残的主要原因之一,通常始于青春期。青少年抑郁症常导致学业失败、同伴关系不佳、行为问题、家庭及社会关系冲突,甚至自杀等不良后果,早期预防和积极有效的治疗至关重要。磁共振扩散张量成像技术能定量评价脑白质微结构,构建结构网络,可用于分析青少年抑郁症患者脑白质异常与症状、年龄、性别等临床变量的相关性。青少年抑郁症扩散张量成像研究显示,青少年抑郁症患者存在胼胝体、扣带束及钩状束等多个白质纤维束微结构异常,前额叶-纹状体环路、前额叶-边缘系统神经环路受损,且与记忆、情绪调节、奖励处理、认知加工等密切相关,与成人抑郁症中的发现一致。本研究对扩散张量成像的成像原理、数据处理方法及在青少年抑郁症中的应用进展进行简要综述,为今后的研究提供新思路。Depression is one of the leading causes of disability,and it usually begins during adolescence.It is well known that depression often leads to academic failure,poor peer relationships,behavioral problems,conflict with family and social relationships,and even suicide in adolescents.It is very urgent to take active and effective prevention and treatment for adolescent depression.Diffusion tensor imaging can evaluate white matter microstructure and build structural brain networks.In addition,it can be used to analyze the correlation between white matter abnormalities and clinical symptoms,age,gender and other clinical variables in adolescent depression.In recent years,diffusion tensor imaging studies on adolescent depression have shown that the abnormal microstructure of several white matter fiber tracts such as the corpus callosum,cingulate tract and uncinate tract,as well as the damaged neural circuits of the prefrontal striatum and prefrontal limbic system have been confirmed in adolescent depression,which is closely related to memory,emotion management,reward and cognitive processing.The results are consistent with findings in adult depression.This article will briefly review the principle of diffusion tensor imaging,data processing methods and its application in adolescent depression,aiming to provide new ideas for future research.

关 键 词：抑郁症 青少年 弥散张量成像 白质 结构性脑网络 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]