陶瓷膜分离技术及其在生物制造领域的应用进展  

Progress of ceramic membrane separation technology and its application in bio-manufacturing field

作　　者：张锐 江静 徐鸿飞 杨盛凯 李亚红 周靖原 曾坚贤[1] 黄小平 刘鹏飞 张明明[2] 李志强 ZHANG Rui;JIANG Jing;XU Hongfei;YANG Shengkai;LI Yahong;ZHOU Jingyuan;ZENG Jianxian;HUANG Xiaoping;LIU Pengfei;ZHANG Mingming;LI Zhiqiang(College of Chemistry and Chemical Engineering,Hunan University of Science and Technology,Xiangtan 411201,Hunan,China;Office of Asset Management and Laboratory Management,Hunan University of Science and Technology,Xiangtan 411201,Hunan,China;Hunan Evershine Membrane Technology Co.,Ltd.,Changsha 410205,Hunan,China)

机构地区：[1]湖南科技大学化学化工学院,湖南湘潭411201 [2]湖南科技大学国有资产与实验室管理处,湖南湘潭411201 [3]湖南恒辉膜科技有限公司,湖南长沙410205

出　　处：《化工进展》2024年第8期4550-4561,共12页Chemical Industry and Engineering Progress

基　　金：湖南省自然科学基金(2022JJ30238);湖南省教育厅重点科学研究项目(21A0291);大学生创新创业训练计划(S202310534060,S202310534134)。

摘　　要：陶瓷膜分离技术因具有高通量、抗污性能好、易清洗、生命周期长等优点而得到广泛应用。然而,受限于对陶瓷膜的特点、优势和用途等方面的认知,该技术在飞速发展的生物制造领域应用相对有限。本文首先介绍了陶瓷膜分离技术及分类,简述了陶瓷膜的优势以及陶瓷膜组件和国内外生产厂家。此外,重点综述了生物制药、生物基材料、生物能源、大宗发酵产品和发酵食品饮料等生物制造领域的产品特点以及陶瓷膜的应用实例,并根据发酵液的分离目的,从膜的材料、结构、孔径、操作和清洗方法等方面分析了陶瓷膜的选择策略。最后,指出了低成本和高分离精度的陶瓷膜研发是拓宽其在生物制造领域应用的重要方向,同时,进一步积累陶瓷膜在生物制造领域的应用案例和数据,提高产品质量和膜的使用寿命,降低成本,将促进陶瓷膜技术在快速发展的生物制造领域更加广泛的应用,落实“双碳”战略目标。Ceramic membrane separation technology is widely used due to the advantages of high flux,good anti-fouling performance,easy cleaning,and long lifespan.However,the limited understanding of the characteristics,advantages and uses of ceramic membrane has greatly restricted the application of this technology in the fast-developing field of bio-manufacturing industry in the past years.This paper introduced the ceramic membrane separation technology and classification,and described the advantages of ceramic membranes and domestic and foreign manufacturers.The bio-product characteristics and application examples of ceramic membrane in bio-manufacturing fields including biopharmaceuticals,bio-based materials,bioenergy,bulk fermented products and fermented food and beverage were reviewed systematically.The selection strategies for ceramic membranes application were analyzed from the aspects of membrane material,configuration,pore size,operation and cleaning method according to the separation purpose of fermentation liquid.The article pointed out that the development of ceramic membrane with low cost and high separation accuracy was an important direction to expand its application in bio-manufacturing field.Meanwhile,further accumulating ceramic membrane application cases and data in bio-manufacturing fields in future researches,improving product quality and membrane lifespan,and reducing the cost would promote more extensive application of the ceramic membrane technology in the fast-developing bio-manufacturing industry,and the implement of the carbon peaking and carbon neutrality goals.

关 键 词：生物分离 膜 发酵 陶瓷 生物制造 

分 类 号：TQ028[化学工程]