信号转导与转录激活因子3对细胞的稳态调节及调控肉色影响机制的研究进展  

Research Progress in the Regulation of Cellular Homeostasis and the Mechanism of Meat Color Regulation by Signal Transducer and Activator of Transcription 3

作　　者：赵文秀 杜瑞 杜雪蓉 董玉珊 李晨龙 姚丽丽 侯艳茹 张静[1] 罗玉龙 ZHAO Wenxiu;DU Rui;DU Xuerong;DONG Yushan;LI Chenlong;YAO Lili;HOU Yanru;ZHANG Jing;LUO Yulong(School of Food Science and Engineering,Ningxia University,Yinchuan 750021,China;Yinchuan Agricultural Product Quality Testing Center,Yinchuan 750000,China)

机构地区：[1]宁夏大学食品科学与工程学院,宁夏银川750021 [2]银川市农产品质量检测中心,宁夏银川750000

出　　处：《食品科学》2024年第18期242-249,共8页Food Science

基　　金：国家自然科学基金青年科学基金项目(32202135);宁夏自治区自然科学基金项目(2021AAC03098);宁夏青年科技人才托举工程项目。

摘　　要：信号转导与转录激活因子3(signal transducer and activator of transcription 3,STAT3)存在于细胞质、细胞核、线粒体及线粒体相关内质网膜中,是参与细胞增殖、分化、迁移和免疫调节等多种生理过程的信号转导蛋白。本文概述了STAT3的结构、类型及进入线粒体的途径;阐述了STAT3对细胞的稳态调节,包括介导内质网Ca^(2+)转运的细胞抗凋亡作用、维持线粒体功能的作用机制和对脂质合成与分解代谢的调控机制,进一步从对造血干细胞的调控作用、骨骼肌的调节、线粒体稳态调节和对脂肪合成与代谢的调控等方面探讨了STAT3调控肉色的机制,以期为改善肉色提供理论参考。Signal transducer and activator of transcription 3(STAT3)exists in the cytoplasm,nucleus,mitochondria,and mitochondria associated endoplasmic reticulum membranes,which is a signal transduction protein involved in various physiological processes such as cell proliferation,differentiation,migration,and immune regulation.This article provides an overview of the structures and types of STAT3 and the pathways through which STAT3 enters mitochondria,and elaborates on the regulatory effect of STAT3 on cellular homeostasis including the anti-apoptotic effect mediated by endoplasmic reticulum Ca^(2+)transport,the mechanism of action in maintaining mitochondrial function,and the regulatory mechanism on lipid synthesis and catabolism.Furthermore,this paper explores the regulatory mechanism of STAT3 on meat color from the perspective of regulating hematopoietic stem cells,skeletal muscle,mitochondrial homeostasis,and lipid synthesis and metabolism in order to provide a theoretical reference for improving meat color.

关 键 词：信号转导与转录激活因子3 线粒体稳态 肌红蛋白 自由基 肉色稳定性 

分 类 号：TS251.52[轻工技术与工程—农产品加工及贮藏工程]