Beta-alanine promotes angiogenesis in laser-induced choroidal neovascularization mice models  

作　　者：Jia-Li Wu Min Zhang Xiao-Dong Sun 

机构地区：[1]Department of Ophthalmology,Shanghai General Hospital(Shanghai First People’s Hospital),Shanghai Jiao Tong University,School of Medicine,Shanghai 200080,China [2]National Clinical Research Center for Ophthalmic Diseases,Shanghai 200080,China [3]National Clinical Research Center for Eye Diseases,Shanghai 200080,China [4]Shanghai Key Laboratory of Fundus Diseases,Shanghai 200080,China [5]Shanghai Engineering Center for Visual Science and Photomedicine,Shanghai 200080,China

出　　处：《International Journal of Ophthalmology(English edition)》2024年第9期1592-1598,共7页国际眼科杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.82171076,No.82301221);Shanghai Municipal Education Commission(No.2023ZKZD18).

摘　　要：AIM:To investigate the effect ofβ-alanine(BA)on laserinduced choroidal neovascularization(CNV)mice models.METHODS:Laser-induced CNV mice models were established,and BA was administrated for one week and two weeks in advance,separately.Furthermore,retinal pigment epithelium(RPE)-choroid flat mounts were separated,and immunohistochemical staining was performed.The laser-induced CNV lesion areas were measured and compared.In addition,liver and kidney morphologies were observed to identify potential hepatorenal toxicity.RESULTS:Enlarged CNV lesion areas were observed in the BA treated group.No significant differences were observed in the liver and kidney sections between groups.CONCLUSION:BA treatment increase CNV lesion areas,suggesting the detrimental effects of BA as a nutritional supplement in age-related macular degeneration(AMD)population.

关 键 词：age-related macular degeneration choroidal neovascularization Β-ALANINE ANGIOGENESIS 

分 类 号：R774.5[医药卫生—眼科]