香菇多糖辅助FOLFOX4化疗在晚期胃癌患者中的应用  

Application of lentinan assisted FOLFOX4 chemotherapy in the treatment of advanced gastric cancer patients

作　　者：贾琪 张巍巍[1] 刘其伟 JIA Qi;ZHANG Weiwei;LIU Qiwei(Department of TumorⅡ,the First People′s Hospital of Nanyang,Nanyang 473000,China)

机构地区：[1]南阳市第一人民医院肿瘤二科,南阳473000

出　　处：《华夏医学》2024年第3期93-98,共6页Acta Medicinae Sinica

基　　金：河南省科技攻关项目(20210231069)。

摘　　要：目的观察香菇多糖辅助奥沙利铂联合氟尿嘧啶(FOLFOX4)化疗对晚期胃癌近期效果及预后情况的影响。方法选取100例晚期胃癌患者作为研究对象,按照随机数字表法分为两组,每组50例。两组患者均实施FOLFOX4化疗,仅联合组采用香菇多糖辅助治疗,两组治疗后均开展为期1年的随访,比较两组患者的近期治疗效果及短期预后情况。结果在不同治疗方案下,联合组血管内皮生长因子(VEGF)、白细胞介素-10(IL-10)的水平均低于化疗组,差异有统计学意义(P<0.05);联合组T淋巴细胞亚群CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)的水平均高于化疗组(P<0.05);癌胚抗原(CEA)、糖类抗原199(CA199)、糖类抗原242(CA242)的水平均低于化疗组(P<0.05);联合组客观缓解率(ORR)、疾病控制率(DCR)均高于化疗组(P<0.05);随访结束时,联合组的中位无进展生存期(PFS)、中位总生存期(OS)均长于化疗组(P<0.05)。结论香菇多糖辅助FOLFOX4化疗能增强晚期胃癌患者的近期疗效,对改善患者短期预后也有积极意义。Objective To observe the effect of lentinan assisted FOLFOX4 chemotherapy on the short-term efficacy and long-term prognosis of advanced gastric cancer.Methods 100 patients with advanced gastric cancer were selected as the research subjects,and randomly divided into two groups using a random number table method,with 50 cases in each group.Both groups of patients were received FOLFOX4 chemotherapy,while the combination group were received adjuvant treatment with lentinan.After treatment,both groups were followed up for 1 year to compare their short-term efficacy and prognosis.Results Under different treatment regimens,the levels of vascular endothelial growth factor(VEGF)and interleukin-10(IL-10)in the combination group were lower than those in the chemotherapy group,showing a statistically significant difference(P<0.05);the subsets of T lymphocytes CD3^(+),CD4^(+),CD4^(+)/CD8^(+)were all higher than those in the chemotherapy group(P<0.05);the levels of carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199),and carbohydrate antigen 242(CA242)were all lower than those in the chemotherapy group(P<0.05);the objective response rate(ORR)and disease control rate(DCR)were higher than those in the chemotherapy group(P<0.05);as of the end of follow-up,the median progression free survival(PFS)and median overall survival(OS)in the combination group were higher than those in the chemotherapy group(P<0.05).Conclusion Lentinan assisted FOLFOX4 chemotherapy enhances the short-term efficacy of advanced gastric cancer patients and ha positive implications for improving their short-term prognosis.

关 键 词：晚期胃癌 香菇多糖 FOLFOX4化疗 近期疗效 短期预后 

分 类 号：R735[医药卫生—肿瘤]