口苦病因和治疗的研究进展  

Research advances in the etiology and treatment of bitter taste in the mouth

作　　者：杨治鑫 王冏珂 明婕妤 曾昕[1] 陈谦明[1] YANG Zhixin;WANG Jiongke;MING Jieyu;ZENG Xin;CHEN Qianming(Department of Oral Medicine,West China Hospital of Sto-matology,Sichuan University&State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Research Unit of Oral Carcinogenesis and Management,Chinese Academy of Medical Sciences,Chengdu 610041,China)

机构地区：[1]四川大学华西口腔医院口腔黏膜病科,口腔疾病防治全国重点实验室,国家口腔疾病临床医学研究中心,中国医学科学院口腔黏膜癌变与防治创新单元,四川成都610041

出　　处：《口腔医学》2024年第8期609-616,共8页Stomatology

基　　金：国家自然科学基金(U19A2005,82270986,82201074)。

摘　　要：口苦是一种常见的临床症状,是指在排除饮食等外部因素后口腔内自觉出现苦味,属于味觉障碍中的味幻觉。口苦的病因和机制目前尚不明确,研究表明口苦主要与疾病、药物、营养等多种因素相关,也尚未形成有效可靠的治疗方案。本文从病因、机制和治疗等方面总结了关于口苦的最新研究进展,旨在为口苦患者的临床诊疗提供参考。Bitter taste in the mouth is a prevalent clinical symptom that refers to a spontaneous bitterness in the mouth after excluding external factors such as diet,and belongs to the phantogeusia of dysgeusia.The etiology and mechanism of bitter taste in the mouth re⁃main unclear.Studies have shown that bitter taste in the mouth is mainly associated with multiple factors such as diseases,medications and nutrition.In addition,effective and reliable treatments have also not yet been developed.This paper reviews the latest research ad⁃vances in the etiology,mechanism and treatment of bitter taste in the mouth,with the aim of providing reference for the clinical man⁃agement of patients with mouth bitterness.

关 键 词：苦味 口苦 味幻觉 味觉障碍 

分 类 号：R781[医药卫生—口腔医学]