A review on anti-inflammation activity of phenol compound paeonol  

作　　者：Weitao Zhong Hao Hu Jiaqing Cao Xinnan Li Xiangrong Zhang 

机构地区：[1]Faculty of Functional Food and Wine,Shenyang Pharmaceutical University,Shenyang 110016,China [2]Liaoning Inspection Examination and Certifi cation Centre,Shenyang 110031,China

出　　处：《Journal of Polyphenols》2024年第3期106-116,共11页多酚杂志（英文）

摘　　要：Paeonol is a bioactive phenol present in Dioscorea japonica,Paeonia suff ruticosa and Paeonia lactiflora.It is the main active ingredient in the traditional Chinese medicines Mudanpi and Xu Changqing.Clinical applications of paeonol are mainly focused on anti-inflammatory effects due to its ability to act as an antioxidant,a regulator of inflammatory enzyme activities,a modulator of inflammatory signaling pathways and a regulator of adhesion molecules to modulate inflammation through molecular mechanisms of action.In addition,paeonol also regulates inflammation by regulating the metabolism of gut microbes.In this review,we searched PubMed,Web of Science,ESI and other websites using“paeonol”“inflammation”“oxidative stress”“signaling pathways”and“gut microbiota”as keywords.We mainly referred to the relevant literature in the last decade and systematically summarized the studies on the anti-inflammatory effects of paeonol to provide a reference for new drug development and clinical application of paeonol.

关 键 词：PAEONOL INFLAMMATION molecular mechanisms gut microbes 

分 类 号：R284[医药卫生—中药学]