Neuronal and synaptic adaptations underlying the benefits of deep brain stimulation for Parkinson’s disease  

作　　者：Wenying Xu Jie Wang Xin-Ni Li Jingxue Liang Lu Song Yi Wu Zhenguo Liu Bomin Sun Wei-Guang Li 

机构地区：[1]Department of Rehabilitation Medicine,Huashan Hospital,Institute for Translational Brain Research,State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain Science,Fudan University,Shanghai 200032,China [2]Department of Neurosurgery,Center for Functional Neurosurgery,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China [3]Department of Neurology,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China [4]Ministry of Education-Shanghai Key Laboratory for Children’s Environmental Health,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China

出　　处：《Translational Neurodegeneration》2023年第1期90-110,共21页转化神经变性病（英文）

基　　金：supported by grants from the STI2030-Major Projects(2022ZD0208605);the National Natural Science Foundation of China(32071023,82271274,82171242);the Science and Technology Commission of Shanghai Municipality(22XD1420700);the Shanghai Municipal Health Commission(2022XD046);innovative research team of high-level local universities in Shanghai(SHSMU-ZDCX20211901).

摘　　要：Deep brain stimulation(DBS)is a well-established and effective treatment for patients with advanced Parkinson’s disease(PD),yet its underlying mechanisms remain enigmatic.Optogenetics,primarily conducted in animal models,provides a unique approach that allows cell type-and projection-specific modulation that mirrors the frequency-dependent stimulus effects of DBS.Opto-DBS research in animal models plays a pivotal role in unraveling the neuronal and synaptic adaptations that contribute to the efficacy of DBS in PD treatment.DBS-induced neuronal responses rely on a complex interplay between the distributions of presynaptic inputs,frequency-dependent synaptic depression,and the intrinsic excitability of postsynaptic neurons.This orchestration leads to conversion of firing patterns,enabling both antidromic and orthodromic modulation of neural circuits.Understanding these mechanisms is vital for decoding position-and programming-dependent effects of DBS.Furthermore,patterned stimulation is emerging as a promising strategy yielding long-lasting therapeutic benefits.Research on the neuronal and synaptic adaptations to DBS may pave the way for the development of more enduring and precise modulation patterns.Advanced technologies,such as adaptive DBS or directional electrodes,can also be integrated for circuit-specific neuromodulation.These insights hold the potential to greatly improve the effectiveness of DBS and advance PD treatment to new levels.

关 键 词：Parkinson’s disease Deep brain stimulation OPTOGENETICS Opto-DBS Synaptic adaptation Orthodromic effects Antidromic effects Long-lasting therapeutic effects 

分 类 号：R742.5[医药卫生—神经病学与精神病学]