Recent advances on the molecular mechanisms of exercise-induced improvements of cognitive dysfunction  

作　　者：Yi Lu Fa-Qian Bu Fang Wang Li Liu Shuai Zhang Guan Wang Xiu-Ying Hu 

机构地区：[1]West China School of Nursing,Sichuan University/Innovation Center of Nursing Research,Nursing Key Laboratory of Sichuan Province,State Key Laboratory of Biotherapy and Cancer Center,National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University,Chengdu 610041,China

出　　处：《Translational Neurodegeneration》2023年第1期745-765,共21页转化神经变性病（英文）

基　　金：supported by the National Natural Science Foundation of China(22177083);West China Nursing Discipline Development Special Fund Project,Sichuan University(HXHL21011,HXHL20015);Sichuan Science and Technology Program(2022NSFSC1290,2022NSFSC1393,and 2021YJ0016).

摘　　要：Physical exercise is of great significance for maintaining human health.Exercise can provide varying degrees of benefits to cognitive function at all stages of life cycle.Currently,with the aging of the world’s population and increase of life expectancy,cognitive dysfunction has gradually become a disease of high incidence,which is accompanied by neurodegenerative diseases in elderly individuals.Patients often exhibit memory loss,aphasia and weakening of orientation once diagnosed,and are unable to have a normal life.Cognitive dysfunction largely affects the physical and mental health,reduces the quality of life,and causes a great economic burden to the society.At present,most of the interventions are aimed to maintain the current cognitive level and delay deterioration of cognition.In contrast,exercise as a nonpharmacological therapy has great advantages in its nontoxicity,low cost and universal application.The molecular mechanisms underlying the effect of exercise on cognition are complex,and studies have been extensively centered on neural plasticity,the direct target of exercise in the brain.In addition,mitochondrial stability and energy metabolism are essential for brain status.Meanwhile,the organ-brain axis responds to exercise and induces release of cytokines related to cognition.In this review,we summarize the latest evidence on the molecular mechanisms underlying the effects of exercise on cognition,and point out directions for future research.

关 键 词：EXERCISE Cognitive function Molecular mechanism Neurodegenerative disease Nonpharmacological therapy 

分 类 号：R749.1[医药卫生—神经病学与精神病学]