Role of inflammation in neurological damage and regeneration following spinal cord injury and its therapeutic implications  

作　　者：Yan Jin Yixing Song Jiaqi Lin Tianqing Liu Guicai Li Biqin Lai Yun Gu Gang Chen Lingyan Xing 

机构地区：[1]Key Laboratory of Neuroregeneration of Jiangsu and the Ministry of Education,Co-innovation Center of Neurore-generation,NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products,Nantong University,Nantong 226006,China [2]School of Life Sciences,Nantong University,Nantong 226019,China [3]School of Medicine,Nantong University,Nantong 226006,China [4]NICM Health Research Institute,Western Sydney University,Westmead,NSW 2145,Australia [5]Key Laboratory for Stem Cells and Tissue Engineering(Sun Yat-sen University),Ministry of Education,Guangzhou 510275,China [6]Co-innovation Center of Neuroregeneration,Nantong Univer-sity,Nantong 226006,China

出　　处：《Burns & Trauma》2023年第1期62-71,共10页烧伤与创伤（英文）

基　　金：supported by the National Key R&D Program of China(2022YFA1105900);the National Natural Science Foundation of China(81701127);the Nantong Science and Technology Foundation of China(JC2021058);the Large Instruments Open Foundation of Nantong University(KFJN2231,KFJN2275).

摘　　要：Spinal cord injury(SCI)is an incurable trauma that frequently results in partial or complete loss of motor and sensory function.Massive neurons are damaged after the initial mechanical insult.Secondary injuries,which are triggered by immunological and inflammatory responses,also result in neuronal loss and axon retraction.This results in defects in the neural circuit and a deficiency in the processing of information.Although inflammatory responses are necessary for spinal cord recovery,conflicting evidence of their contributions to specific biological processes have made it difficult to define the specific role of inflammation in SCI.This review summarizes our understanding of the complex role of inflammation in neural circuit events following SCI,such as cell death,axon regeneration and neural remodeling.We also review the drugs that regulate immune responses and inflammation in the treatment of SCI and discuss the roles of these drugs in the modulation of neural circuits.Finally,we provide evidence about the critical role of inflammation in facilitating spinal cord neural circuit regeneration in zebrafish,an animal model with robust regenerative capacity,to provide insights into the regeneration of the mammalian central nervous system.

关 键 词：INFLAMMATION Immune response Spinal cord injury Axon regeneration Cell death ZEBRAFISH Inflammatory drugs Trauma Neurological damage 

分 类 号：R651.2[医药卫生—外科学]