Autophagy in the pathogenesis and therapeutic potential of post-traumatic osteoarthritis  

作　　者：Yunquan Gong Song Li Jinghui Wu Tongyi Zhang Shunzheng Fang Daibo Feng Xiaoqing Luo Jing Yuan Yaran Wu Xiaojing Yan Yan Zhang Jun Zhu Jiangyi Wu Jiqin Lian Wei Xiang Zhenhong Ni 

机构地区：[1]State Key Laboratory of Trauma,Burns and Combined Injury,Department of Rehabilitation Medicine,Daping Hospital,Army Medical University,Changjiang Street,Yuzhong District,Chongqing 400042,China [2]Department of Orthopedics,Shanghai Hospital,Shanghai Street,Wanzhou District,Chongqing 404000,China [3]Department of Wound Repair and Rehabilitation Medicine,Center of Bone Metabolism and Repair,Laboratory for Prevention and Rehabilitation of Training Injuries,State Key Laboratory of Trauma,Burns and Combined Injury,Trauma Center,Research Institute of Surgery,Daping Hospital,Army Medical University,Changjiang Street,Yuzhong District,Chongqing 400042,China [4]Joint Surgery and Sport Medicine Department,Hunan Provincial People’s Hospital,the First Affiliated Hospital of Hunan Normal University,Jiefangxi Street,Furong District,Changsha 410005,China [5]Department of General practice,Chinese PLA General Hospital of the Central Theater Command,Wuluo Street,Wuchang District,Wuhan 430000,China [6]Department of Biochemistry and Molecular Biology,College of Basic Medical Sciences,Army Medical University,Gantaoyan Street,Shapinba District,Chongqing 400038,China [7]Department of Clinical Biochemistry,Faculty of Pharmacy and Laboratory Medicine,Army Medical University,Gantaoyan Street,Shapinba District,Chongqing 400038,China [8]Department of Pediatrics,People’s Hospital Affiliated to Chongqing Three Gorges Medical College,Guoben Street,Wanzhou district,Chongqing 404000,China [9]Department of Cardiology,Shanghai Hospital,Shanghai Street,Wanzhou District,Chongqing 404000,China [10]Department of Sports Medicine and Rehabilitation,Shenzhen Hospital,Peking University,Lianhua Street,Futian District,Shenzhen 518034,China

出　　处：《Burns & Trauma》2023年第1期155-175,共21页烧伤与创伤（英文）

基　　金：funding by the National Natural Science Foundation of China(No.81871817,No.82202770,No.81802205);the Natural Science Foundation of Chongqing(No.CSTB2022NSCQMSX1267,No.CSTB2022NSCQ-MSX0863);the Laboratory Project of State Key Laboratory of Trauma,Burn and Combined Injury(No.SKL2021JY01);the Military Project of PLA(No.2020XYY11,No.21WQ002,No.2019HQZX03).

摘　　要：Autophagy,as a fundamental mechanism for cellular homeostasis,is generally involved in the occurrence and progression of various diseases.Osteoarthritis(OA)is the most common muscu-loskeletal disease that often leads to pain,disability and economic loss in patients.Post-traumatic OA(PTOA)is a subtype of OA,accounting for>12%of the overall burden of OA.PTOA is often caused by joint injuries including anterior cruciate ligament rupture,meniscus tear and intra-articular fracture.Although a variety of methods have been developed to treat acute joint injury,the current measures have limited success in effectively reducing the incidence and delaying the progression of PTOA.Therefore,the pathogenesis and intervention strategy of PTOA need further study.In the past decade,the roles and mechanisms of autophagy in PTOA have aroused great interest in the field.It was revealed that autophagy could maintain the homeostasis of chondrocytes,reduce joint inflammatory level,prevent chondrocyte death and matrix degradation,which accordingly improved joint symptoms and delayed the progression of PTOA.Moreover,many strategies that target PTOA have been revealed to promote autophagy.In this review,we summarize the roles and mechanisms of autophagy in PTOA and the current strategies for PTOA treatment that depend on autophagy regulation,which may be beneficial for PTOA patients in the future.

关 键 词：AUTOPHAGY Post-traumatic osteoarthritis MTOR Noncoding RNAs 

分 类 号：R68[医药卫生—骨科学]