Emerging roles of mitochondria in animal regeneration  

作　　者：Yun Zhao Chong Gao Xue Pan Kai Lei 

机构地区：[1]Westlake Laboratory of Life Sciences and Biomedicine,Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province,School of Life Sciences,Westlake University,Hangzhou,Zhejiang 310024,China [2]Institute of Biology,Westlake Institute for Advanced Study,Hangzhou,Zhejiang 310024,China [3]Fudan University,Shanghai,China [4]Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province,School of Medicine,Hangzhou City University,Hangzhou,China [5]College of Life Sciences,Zhejiang University,Hangzhou,Zhejiang,China

出　　处：《Cell Regeneration》2023年第1期234-244,共11页细胞再生（英文）

基　　金：supported by Westlake Education Foundation.K.L.;supported by the National Natural Science Foundation of China(32122032 and 31970750 to K.L.,32000498 to C.G.).

摘　　要：The regeneration capacity after an injury is critical to the survival of living organisms.In animals,regeneration ability can be classified into five primary types:cellular,tissue,organ,structure,and whole-body regeneration.Multiple organelles and signaling pathways are involved in the processes of initiation,progression,and completion of regeneration.Mitochondria,as intracellular signaling platforms of pleiotropic functions in animals,have recently gained attention in animal regeneration.However,most studies to date have focused on cellular and tissue regeneration.A mechanistic understanding of the mitochondrial role in large-scale regeneration is unclear.Here,we reviewed findings related to mitochondrial involvement in animal regeneration.We outlined the evidence of mitochondrial dynamics across different animal models.Moreover,we emphasized the impact of defects and perturbation in mitochondria resulting in regeneration failure.Ultimately,we discussed the regulation of aging by mitochondria in animal regeneration and recommended this for future study.We hope this review will serve as a means to advocate for more mechanistic studies of mitochondria related to animal regeneration on different scales.

关 键 词：MITOCHONDRIA REGENERATION PLANARIA Aging Model organisms 

分 类 号：R33[医药卫生—人体生理学]