Zebrafish:a convenient tool for myelopoiesis research  

作　　者：Yang‑Xi Hu Qing Jing 

机构地区：[1]Department of Cardiology,Changzheng Hospital,Shanghai 200003,China [2]CAS Key Laboratory of Tissue Microenvironment and Tumor,Shanghai Institute of Nutrition and Health,Chinese Academy of Sciences,320 Yue‑Yang Road,Shanghai 200031,China

出　　处：《Cell Regeneration》2023年第1期447-460,共14页细胞再生（英文）

基　　金：supported in part by the National Key Research and Development Program of China(2019YFA0802700);the National Natural Science Foundation of China(92168206).

摘　　要：Myelopoiesis is the process in which the mature myeloid cells,including monocytes/macrophages and granulocytes,are developed.Irregular myelopoiesis may cause and deteriorate a variety of hematopoietic malignancies such as leukemia.Myeloid cells and their precursors are difficult to capture in circulation,let alone observe them in real time.For decades,researchers had to face these difficulties,particularly in in-vivo studies.As a unique animal model,zebrafish possesses numerous advantages like body transparency and convenient genetic manipulation,which is very suitable in myelopoiesis research.Here we review current knowledge on the origin and regulation of myeloid development and how zebrafish models were applied in these studies.

关 键 词：MYELOPOIESIS Hematopoietic stem/progenitor cells Myeloid disorder ZEBRAFISH 

分 类 号：Q46[生物学—生理学]