MYELOPOIESIS

作品数：13被引量：17H指数：2
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相关机构：东南大学更多>>
相关期刊：《Signal Transduction and Targeted Therapy》《Cellular & Molecular Immunology》《Science China(Life Sciences)》《The Innovation》更多>>
相关基金：国家自然科学基金广东省自然科学基金国家重点基础研究发展计划更多>>
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FHL2 deficiency aggravates Candida albicans infection through decreased myelopoiesis
《Science China(Life Sciences)》2025年第3期722-733,共12页Rongmei Gao Kanchao Chen Yimin Wang Rongxia Guo Xiaoyu Zhang Peng Wu Weili Wang Qingxiang Huang Xuemei Xie Shangda Yang Yanling Lv Qian Ren Fei Liu Song Chen Fengxia Ma Tao Cheng Hui Cheng 
supported by the National Key Research and Development Program of China(2020YFE0203000,2021YFA1100900);the National Natural Science Foundation of China(92368202,82270120);the Haihe Laboratory of Cell Ecosystem Innovation Fund(22HHXBSS00016);the CAMS Initiative for Innovative Medicine(2021-I2M-1-019,2022-I2M-2-001);the CAMS Fundamental Research Funds for Central Research Institutes(3332021093).
Hematopoiesis is a finely tuned process that generates all blood cell types through self-renewal and differentiation,which is crucial for maintaining homeostasis.Acute infections can prompt a hematopoietic response kn...
关键词：fungal infection emergency myelopoiesis FHL2 
Age-associated imbalance in immune cell regeneration varies across individuals and arises from a distinct subset of stem cells
《Cellular & Molecular Immunology》2024年第12期1459-1473,共15页Anna Nogalska Jiya Eerdeng Samir Akre Mary Vergel-Rodriguez Yeachan Lee Charles Bramlett Adnan Y.Chowdhury Bowen Wang Colin G.Cess Stacey D.Finley Rong Lu 
supported by NIH-R00-HL113104,R01HL138225,and R35HL150826;R.Lu is a scholar of the Leukemia&Lymphoma Society(LLS-1370-20);The project described was supported in part by award number P30CA014089 from the National Cancer Institute;CB is supported by National Institutes of Health grant 1F31HL149278-01A1;JE is supported by the California Institute for Regenerative Medicine grant EDUC4-12756.
The age-associated decline in immunity manifests as imbalanced adaptive and innate immune cells,which originate from the aging of the stem cells that sustain their regeneration.Aging variation across individuals is we...
关键词：aging clonal tracking hematopoietic stem cells lineage bias MYELOPOIESIS 
Integrative cross-species transcriptome analysis reveals earlier occurrence of myelopoiesis in pre-circulation primates compared to mice
《Zoological Research》2024年第6期1276-1286,共11页Junjie Du Zongcheng Li Yandong Gong Yu Lan Bing Liu 
supported by the Beijing Natural Science Foundation(5222035);Beijing Nova Program(Z211100002121033,20230484407);National Key R&D Program of China(2021YFA0805703,2021YFA1100901,2022YFA1105700);National Natural Science Foundation of China(31930054,32100646,82370107,82270118);Program for Guangdong Introducing Innovative and Entrepreneurial Teams(2017ZT07S347)。
Hematopoiesis originates in the yolk sac,which forms prior to the establishment of blood circulation and exhibits distinct developmental processes between primates and mice.Despite increasing appreciation of yolk sac ...
关键词：Yolk sac HEMATOPOIESIS Macrophage Integrative analysis Single-cell RNA sequencing 
Zebrafish:a convenient tool for myelopoiesis research
《Cell Regeneration》2023年第1期447-460,共14页Yang‑Xi Hu Qing Jing 
supported in part by the National Key Research and Development Program of China(2019YFA0802700);the National Natural Science Foundation of China(92168206).
Myelopoiesis is the process in which the mature myeloid cells,including monocytes/macrophages and granulocytes,are developed.Irregular myelopoiesis may cause and deteriorate a variety of hematopoietic malignancies suc...
关键词：MYELOPOIESIS Hematopoietic stem/progenitor cells Myeloid disorder ZEBRAFISH 
Hypothalamic-pituitary-derived melanocortin axis links to myelopoiesis and immunotherapy
《The Innovation》2023年第4期9-10,共2页Chao Zhang Ya-Xiong Tao 
supported by the National Natural Science Foundation of China(grant no.32271165 to Chao Zhang).
Melanocortins,including a-melanocyte stimulating hormone(a-MSH),b-MSH,g-MSH,and adrenocorticotropin(ACTH),are ancient peptides highly conserved in vertebrates and exhibit diverse well-established functions,including d...
关键词：HOMEOSTASIS cortin stimulating 
Traumatic brain injury stimulates sympathetic tone-mediated bone marrow myelopoiesis to favor fracture healing被引量：7
《Signal Transduction and Targeted Therapy》2023年第8期3751-3767,共17页Weijian Liu Wei Chen Mao Xie Chao Chen Zengwu Shao Yiran Zhang Haiyue Zhao Qingcheng Song Hongzhi Hu Xin Xing Xianyi Cai Xiangtian Deng Xinyan Li Peng Wang Guohui Liu Liming Xiong Xiao Lv Yingze Zhang 
This study was partly supported by the National Natural Science Foundation of China(91949203 to Zhang Y.Z.,82102627 to Lv X.);Key Project of Hebei Provincial Natural Fund(H2020206456);Hubei Provincial Natural Science Foundation of China(2021CFB095);Wuhan Knowledge Innovation Project 2022020801020468.
Traumatic brain injury(TBI)accelerates fracture healing,but the underlying mechanism remains largely unknown.Accumulating evidence indicates that the central nervous system(CNS)plays a pivotal role in regulating immun...
关键词：HEALING inflammation TRAUMATIC 
Implications of metabolism-driven myeloid dysfunctions in cancer therapy被引量：2
《Cellular & Molecular Immunology》2021年第4期829-841,共13页Laura Strauss Valentina Guarneri Alessandra Gennari Antonio Sica 
supported by the Associazione Italiana per la Ricerca sul Cancro(AIRC)(IG number 19885 to A.S.);AIRC 5x1000(number 22757);Fondazione Cariplo,and Ministero Universita’Ricerca(MIUR)(project:2017BA9LM5_001);Associazione"Augusto per la Vita",Novellara(RE)and Associazione"Medicine Rocks",Milano.
Immune homeostasis is maintained by an adequate balance of myeloid and lymphoid responses.In chronic inflammatory states,including cancer,this balance is lost due to dramatic expansion of myeloid progenitors that fail...
关键词：MYELOPOIESIS Tumor-associated macrophages Myeloid-derived suppressor cells METABOLISM Cancer therapy 
Decoding early myelopoiesis from dynamics of core endogenous network被引量：1
《Science China(Life Sciences)》2017年第6期627-646,共20页Hang Su Gaowei Wang Ruoshi Yuan Junqiang Wang Ying Tang Ping Ao Xiaomei Zhu 
supported by the National Basic Research Program of China(2010CB529200);National Natural Science Foundation of China(91029738)
A decade ago mainstream molecular biologists regarded it impossible or biologically ill-motivated to understand the dynamics of complex biological phenomena, such as cancer genesis and progression, from a network pers...
关键词：developmental scheme early myeloid cell-fate determination endogenous network stable state transition state landscape 
Cebpa is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish被引量：2
《Journal of Genetics and Genomics》2016年第10期593-600,共8页Yimei Dai Lu Zhu Zhibin Huang Minyu Zhou Wan Jin Wei Liu Mengchang Xu Tao Yu Yiyue Zhang Zilong Wen Wangjun Liao Wenqing Zhang 
supported by the National Natural Science Foundation of China (Nos. 31271564, 31229003 and 31271574);the Team Program of Guangdong Natural Science Foundation (No. 2014A030312002);the Research Grants Council of the HKSAR (Nos. 663212, HKUST5/CRF/12R and AoE /M-09/12)
In vertebrates, myeloid cells arise from multiple waves of development： the first or embryonic wave of myelopoiesis initiates early from non-hematopoietic stem cell（HSC） precursors and gives rise to myeloid cells t...
关键词：CEBPA Embryonic myelopoiesis Development ZEBRAFISH 
Delineation of a novel dendritic-like subset in human spleen
《Cellular & Molecular Immunology》2016年第4期443-450,共8页Sawang Petvises Dipti Talaulikar Helen C O'Neill 
Dendritic cells （DCs） and monocyte subpopulations present in the human spleen were analyzed by flow cytometry in an attempt to identify the presence of a novel dendritic-like cell subset described previously in mice...
关键词：dendritic cells MYELOPOIESIS SPLEEN stroma 
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