胶原蛋白肽促进骨组织再生的研究  

Research on Collagen Peptide Promoting Bone Tissue Regeneration

作　　者：王坤[1] 李卓欣 Wang Kun;Li Zhuoxin(Beijing University of Chemical Technology,Beijing 100029)

机构地区：[1]北京化工大学,北京100029

出　　处：《明胶科学与技术》2023年第4期182-190,共9页The Science and Technology of Gelatin

摘　　要：胶原蛋白肽作为一种天然蛋白水解物,近年来在骨再生领域引起了广泛关注。本文探讨了胶原蛋白肽在促进骨再生方面的潜在机制与应用。研究表明,胶原蛋白肽可以促进成骨细胞和内皮增殖,刺激成骨细胞矿化,对骨组织再生具有明显促进作用。此外,以蛋白EGFR为靶点,应用分子对接计算机模拟方法,获得了一系列具有成骨潜力的多肽。同时,胶原蛋白肽具有良好的生物相容性和生物可降解性,为其在骨再生领域的应用提供了可靠的基础。As a natural protein hydrolysate,collagen peptide has attracted extensive attention in the field of bone regeneration in recent years.The potential mechanism and application of collagen peptides in promoting bone regeneration were discussed.Stud-ies have shown that collagen peptide can promote the proliferation of osteoblasts and endothelial cells,stimulate the mineraliza-tion of osteoblasts,and promote the regeneration of bone tissue.In addition,a series of peptides with osteogenic potential were obtained by molecular docking using EGFR as the target.At the same time,collagen peptide has good biocompatibility and bio-degradability,which provides a reliable basis for its application in the field of bone regeneration.

关 键 词：胶原蛋白肽 骨再生 分子对接 

分 类 号：R318[医药卫生—生物医学工程]