近视父母与子女近视风险的Meta分析  

Meta-analysis of the effect of parental myopia on children's myopia

作　　者：宗晨曦 胡健萍 贾红艳[1] 焦永红[1] Zong Chenxi;Hu Jianping;Jia Hongyan;Jiao Yonghong(Beijing Tongren Eye Center,Beijing Institute of Ophthalmology,Beijing Tongren Hospital,Capital Medical University,Beijing Key Laboratory of Ophthalmology and Visual Science,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院、北京同仁眼科中心、北京市眼科研究所、眼科学与视觉科学北京市重点实验室,100730

出　　处：《眼科》2024年第5期368-376,共9页Ophthalmology in China

基　　金：首都临床诊疗技术研究与转化医学应用(2020-2024,Z100005520034);首都卫生发展科研专项(2024-2026,2024-2G-2057)。

摘　　要：目的系统评价父母近视与子女近视风险之间的关系。设计Meta分析。研究对象46篇关于父母近视对子女近视影响的队列研究、病例对照研究和横断面研究。方法检索PubMed、Web of Science、Embase、中国知网、万方数据库、维普网、中国生物医学文献数据库、中华生物医学文献数据库、中华医学期刊全文数据库中从2000年1月至今2023年9月的关于父母近视对子女近视影响的研究。使用Cochrane手册对纳入文献进行偏倚风险评价及质量评价,并使用STATA 12.0软件进行Meta分析和偏倚检验。主要指标OR值。结果46篇文献共计纳入273376人,其中13项为队列研究,5项为病例对照研究,28项为横断面研究。Meta分析显示,父母中至少一方近视时的病例对照研究、队列研究、横断面研究,子女近视的OR值分别为1.73(95%CI,0.96~3.13)、2.05(95%CI,1.74~2.42)、2.51(95%CI,2.28~2.76);父母一方和双方近视时,子女近视的OR值分别为2.00(95%CI,1.84~2.18)、2.90(95%CI,2.46~3.42)。结论父母近视与儿童患近视的风险之间存在显著的正相关关系,父母一方或双方近视均会显著提高子女的近视风险,父母双方近视的子女相较于父母单方近视的子女近视风险更高。Objective To systematically evaluate the effect of parental myopia on children's myopia.Design Meta analysis.Participants 46 Cohort studies,case-control studies and cross-sectional studies which were conducted for the effects of parental myopia on children's myopia.Methods The literatures in Pubmed,Web of science,Embase,CNKI and Wanfang database VIP and Chinese Biomedical literature Database from the January 2000 to September 2023 were searched.The included literature data were analyzed using the STATA(12.0)software package.Main Outcome Measures OR value.Results A total of 46 literatures(273376 participants)were included,with 13 cohort studies,5 case-control studies and 28 cross-sectional studies.The OR of giving birth to a child with myopia,according to the prospective cohort,cross-sectional and case-control studies was 1.73(95%CI,0.96~3.13),2.05(95%CI,1.74~2.42),2.51(95%CI,2.28~2.76).When one parent had myopia,the OR was 2.00(95%CI,1.84~2.18),respectively,when two parents had myopia,the OR was 2.90(95%CI,2.46-3.42).Conclusion There is a significant positive correlation between parental myopia and the risk of myopia in children.Myopia in one or both parents significantly increases the risk of myopia in their children.Children with myopia in both parents have a higher risk of myopia compared to those with myopia in one parent.

关 键 词：近视 父母近视 META分析 

分 类 号：R778.11[医药卫生—眼科]