An injectable hydrogel combining medicine and matrix with anti-inflammatory and pro-angiogenic properties for potential treatment of myocardial infarction  

作　　者：Jiayin Feng Min Xing Wenhao Qian Jiajun Qiu Xuanyong Liu 

机构地区：[1]State Key Laboratory of High Performance Ceramics and Superfine Microstructure,Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai 200050,China [2]Center of Materials Science and Optoelectronics Engineering,University of Chinese Academy of Sciences,Beijing 100049,China [3]Shanghai Xuhui District Dental Center,Shanghai 200032,China [4]Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine,College of Biological Science and Medical Engineering,Donghua University,Shanghai 201620,China

出　　处：《Regenerative Biomaterials》2023年第1期889-903,共15页再生生物材料（英文版）

基　　金：supported by the National Natural Science Foundation of China(32000945);Young Elite Scientists Sponsorship Program by CAST(YESS)2022-2024QNRC001;Science and Technology Commission of Shanghai Municipality(22ZR1457600,20ZR1452200).

摘　　要：One of the main illnesses that put people’s health in jeopardy is myocardial infarction(MI).After MI,damaged or dead cells set off an initial inflammatory response that thins the ventricle wall and degrades the extracellular matrix.At the same time,the ischemia and hypoxic conditions resulting from MI lead to significant capillary obstruction and rupture,impairing cardiac function and reducing blood flow to the heart.Therefore,attenuating the initial inflammatory response and promoting angiogenesis are very important for the treatment of MI.Here,to reduce inflammation and promote angiogenesis in infarcted area,we report a new kind of injectable hydrogel composed of puerarin and chitosan via in situ self-assembly with simultaneous delivery of mesoporous silica nanoparticles(CHP@Si)for myocardial repair.On the one hand,puerarin degraded from CHP@Si hydrogel modulated the inflammatory response via inhibiting M1-type polarization of macrophages and expression of pro-inflammatory factors.On the other hand,silica ions and puerarin released from CHP@Si hydrogel showed synergistic activity to improve the cell viability,migration and angiogenic gene expression of HUVECs in both conventional and oxygen/glucose-deprived environments.It suggests that this multifunctional injectable CHP@Si hydrogel with good biocompatibility may be an appropriate candidate as a bioactive material for myocardial repair post-MI.

关 键 词：mesoporous silica PUERARIN HYDROGELS ANGIOGENESIS myocardial repair 

分 类 号：TQ427.26[化学工程]