Recent progress in diagnostic imaging and therapeutics of osteosarcoma based on multifunctional nanoparticles  

作　　者：Xueke Yan Danmin Lin Dingyuan Yan Dong Wang Huifang Su 

机构地区：[1]Department of Orthopaedic Surgery,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China [2]Center for AIE Research,College of Materials Science and Engineering,Shenzhen University,Shenzhen 518060,China

出　　处：《Science China Chemistry》2024年第9期2864-2889,共26页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(81902356,82072581,82272842);Henan Province Young and Middle-Aged Health Sciences and Technology Innovation Talent Project(YXKC2022032);Provincial Science and Technology R&D Program Joint Fund of the Department of Science and Technology of Henan Province(Superior Discipline Cultivation Category)Key Project(222301420018);Excellent Young Scientist Foundation of Henan Province(232300421053);Program for Science&Technology Innovation Talents in Universities of Henan Province(24HASTIT066);Young and Middle-Aged Discipline Leader of Henan Provincial Health Commission,Central Plains Science and Technology Innovation Youth Top-Notch Talent Project。

摘　　要：Osteosarcoma is one of the most common primary bone malignancies,mainly occurring in children and adolescents.Traditional diagnosis imaging methods for osteosarcoma contain X-ray,computed tomography and magnetic resonance imaging,and traditional therapy protocols are surgical resection and chemotherapy.However,these strategies are complicated and separated.These imaging methods,despite their maturity,have drawbacks that prevent them from showing more details.What is more,the prognosis for patients with osteosarcoma remains unsatisfactory due to side effects of chemotherapy,as well as incomplete surgical removal of the tumor.To compensate for the shortcomings of traditional imaging and treatment strategies for osteosarcoma,various types of nanoparticles have been designed and synthesized to selectively target osteosarcoma cells without toxic side effects on healthy organs.At the same time,these nanoparticle-based technologies can integrate the imaging and treatment of osteosarcoma.This review summarizes the application of nanotechnology in the imaging and treatment of osteosarcoma in recent years,and finally discusses the challenges and development prospects,aiming to provide ideas for future research.

关 键 词：OSTEOSARCOMA NANOTECHNOLOGY imaging diagnosis THERAPY 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R738.1[医药卫生—肿瘤]