Current challenges in the treatment of gliomas:The molecular era  

作　　者：Castalia Fernández Juan Zafra-Martín Felipe Couñago 

机构地区：[1]Department of Radiation Oncology,GenesisCare Madrid,Madrid 28043,Spain [2]Department of Radiation Oncology,Hospital Universitario Vithas La Milagrosa,GenesisCare,Madrid 28010,Spain [3]Department of Radiation Oncology,Hospital Universitario San Francisco de Asís,GenesisCare,Madrid 28002,Spain [4]Department of Radiation Oncology,Hospital Universitario Virgen de la Victoria,Málaga 29010,Spain

出　　处：《World Journal of Clinical Oncology》2024年第8期982-986,共5页世界临床肿瘤学杂志（英文版）

摘　　要：Gliomas originate from glial cells in the central nervous system.Approximately 80%-85%of malignant brain tumors in adults are gliomas.The most common central nervous system tumor in children is low-grade pediatric glioma.Diagnosis was determined by histological features until 2016 when the World Health Organization classification integrated molecular data with anatomopathological information to achieve a more integral diagnosis.Molecular characterization has led to better diagnostic and prognostic staging,which in turn has increased the precision of treatment.Current efforts are focused on more effective therapies to prolong survival and improve the quality of life of adult and pediatric patients with glioma.However,improvements in survival have been modest.Currently,clinical guidelines,as well as the article by Mohamed et al accompanying this editorial piece,are adapting treatment recommendations(surgery,chemotherapy,and radiotherapy)according to diagnosis and prognosis guided by molecular biomarkers.Furthermore,this paves the way for the design of clinical trials with new therapies,which is especially important in pediatric gliomas.

关 键 词：GLIOMAS CHEMOTHERAPY RADIOTHERAPY Isocitrate dehydrogenase-type mutant Pediatric gliomas ASTROCYTOMA OLIGODENDROGLIOMA 1p/19q-codeleted 

分 类 号：R739.41[医药卫生—肿瘤]