Prevalence of malignant neoplasms in celiac disease patients-a nationwide United States population-based study  

作　　者：Maryam Bilal Haider Ali Al Sbihi Sushmitha Nanja Reddy Peter Green 

机构地区：[1]Department of Gastroenterology,Northshore University Health System,Evanston,IL 60201,United States [2]Department of Hematology/Oncology,University of Miami Miller School of Medicine,Miami,FL 33101,United States [3]Department of Hematology/Oncology,Karmanos Cancer Institute/Wayne State University,Detroit,MI 48235,United States [4]Celiac Disease Center,Columbia University,New York,NY 10032,United States

出　　处：《World Journal of Clinical Oncology》2024年第8期1048-1060,共13页世界临床肿瘤学杂志（英文版）

摘　　要：BACKGROUND Celiac disease(CeD)is an autoimmune disorder triggered by the immune response to gluten in genetically predisposed individuals.Recent research has unveiled a heightened risk of developing specific malignant neoplasms(MN)and various malignancies,including gastrointestinal,lymphomas,skin,and others,in individuals with CeD.AIM To investigate the prevalence of MN in hospitalized CeD patients in the United States.METHODS Using data from the National Inpatient Sample spanning two decades,from January 2000 to December 2019,we identified 529842 CeD patients,of which 78128(14.75%)had MN.Propensity score matching,based on age,sex,race,and calendar year,was employed to compare CeD patients with the general non-CeD population at a 1:1 ratio.RESULTS Positive associations were observed for several malignancies,including small intestine,lymphoma,nonmelanoma skin,liver,melanoma skin,pancreas myelodysplastic syndrome,biliary,stomach,and other neuroendocrine tumors(excluding small and large intestine malignant carcinoid),leukemia,uterus,and testis.Conversely,CeD patients exhibited a reduced risk of respiratory and secondary malignancies.Moreover,certain malignancies showed null associations with CeD,including head and neck,nervous system,esophagus,colorectal,anus,breast,malignant carcinoids,bone and connective tissues,myeloma,cervix,and ovary cancers.CONCLUSION Our study is unique in highlighting the detailed results of positive,negative,or null associations between different hematologic and solid malignancies and CeD.Furthermore,it offers insights into evolving trends in CeD hospital outcomes,shedding light on advancements in its management over the past two decades.These findings contribute valuable information to the understanding of CeD’s impact on health and healthcare utilization.

关 键 词：Celiac disease Malignant neoplasm Autoimmune disorder Hospitalized patients Healthcare utilization Gastrointestinal malignancies LYMPHOMAS EPIDEMIOLOGY 

分 类 号：R73[医药卫生—肿瘤]