Impact of metabolic syndrome components on clinical outcomes in hypertriglyceridemia-induced acute pancreatitis  

作　　者：Zhen-Hua Fu Zi-Yue Zhao Yao-Bing Liang Dong-Yu Cheng Jian-Ming Luo Hai-Xing Jiang Shan-Yu Qin 

机构地区：[1]Department of Gastroenterology,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi Zhuang Autonomous Region,China

出　　处：《World Journal of Gastroenterology》2024年第35期3996-4010,共15页世界胃肠病学杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China,No.82260539;Guangxi Natural Science Foundation,No.2024GXNSFAA010072。

摘　　要：BACKGROUND The incidence of hypertriglyceridemia(HTG)-induced acute pancreatitis(AP)is steadily increasing in China,becoming the second leading cause of AP.Clinical complications and outcomes associated with HTG-AP are generally more severe than those seen in AP caused by other etiologies.HTG-AP is closely linked to metabolic dysfunction and frequently coexists with metabolic syndrome or its components.However,the impact of metabolic syndrome components on HTGAP clinical outcomes remains unclear.AIM To investigate the impact of metabolic syndrome component burden on clinical outcomes in HTG-AP.METHODS In this retrospective study of 255 patients diagnosed with HTG-AP at the First Affiliated Hospital of Guangxi Medical University,we collected data on patient demographics,clinical scores,complications,and clinical outcomes.Subsequently,we analyzed the influence of the presence and number of individual metabolic syndrome components,including obesity,hyperglycemia,hypertension,and low high-density lipoprotein cholesterol(HDL-C),on the aforementioned parameters in HTG-AP patients.RESULTS This study found that metabolic syndrome components were associated with an increased risk of various complications in HTG-AP,with low HDL-C being the most significant risk factor for clinical outcomes.The risk of complications increased with the number of metabolic syndrome components.Adjusted for age and sex,patients with highcomponent metabolic syndrome had significantly higher risks of renal failure[odds ratio(OR)=3.02,95%CI:1.12-8.11)],SAP(OR=5.05,95%CI:2.04-12.49),and intensive care unit admission(OR=6.41,95%CI:2.42-16.97)compared to those without metabolic syndrome.CONCLUSION The coexistence of multiple metabolic syndrome components can synergistically worsen the clinical course of HTGAP,making it crucial to monitor these components for effective disease management.

关 键 词：Hypertriglyceridemia-induced acute pancreatitis Metabolic syndrome High density lipoprotein cholesterol OBESITY HYPERGLYCEMIA HYPERTENSION Clinical outcomes 

分 类 号：R576[医药卫生—消化系统]