Mesenchymal stem cell therapy for liver fibrosis need“partner”:Results based on a meta-analysis of preclinical studies  

作　　者：Yan Xu Xue-Song Wang Xiao-Lei Zhou Wen-Ming Lu Xing-Kun Tang Yu Jin Jun-Song Ye 

机构地区：[1]Subcenter for Stem Cell Clinical Translation,First Affiliated Hospital of Gannan Medical University,Ganzhou 341000,Jiangxi Province,China [2]School of Rehabilitation Medicine,Gannan Medical University,Ganzhou 341000,Jiangxi Province,China [3]Ganzhou Key Laboratory of Stem Cell and Regenerative Medicine,Gannan Medical University,Ganzhou 341000,Jiangxi Province,China [4]Department of Medical Genetics,School of Medicine,Tongji University,Shanghai 200092,China [5]Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases,Ministry of Education,Gannan Medical University,Ganzhou 341000,Jiangxi Province,China

出　　处：《World Journal of Gastroenterology》2024年第32期3766-3782,共17页世界胃肠病学杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China,No.32060232;Jiangxi Provincial Natural Science Foundation,No.20212BAB206075.

摘　　要：BACKGROUND The efficacy of mesenchymal stem cells(MSCs)in treating liver fibrosis has been demonstrated in several clinical studies.However,their low survival and liver implantation rates remain problematic.In recent years,a large number of studies in animal models of liver fibrosis have shown that MSCs combined with drugs can improve the efficacy of MSCs in the treatment of liver fibrosis alone and inhibit its progression to end-stage liver disease.This has inspired new ways of thinking about treating liver fibrosis.AIM To investigate the effectiveness and mechanisms of MSCs combined with drugs in treating liver fibrosis.METHODS Data sources included four electronic databases and were constructed until January 2024.The subjects,interventions,comparators,outcomes,and study design principle were used to screen the literature,and the quality of the literature was evaluated to assess the risk of bias.Relevant randomised controlled trials were selected,and the final 13 studies were included in the final study.RESULTS A total of 13 studies were included after screening.Pooled analysis showed that MSCs combined with drug therapy significantly improved liver function,promoted the repair of damaged liver tissues,reduced the level of liver fibrosis-related indexes,and effectively ameliorated hepatic fibrosis by modulating the hepatic inflammatory microenvironment,promoting the homing of MSCs,and regulating the relevant signaling pathways,and the treatment efficacy was superior to MSCs alone.However,the combined treatment statistics showed no amelioration in serum albumin levels(standardized mean difference=0.77,95%confidence interval:-0.13 to 1.68,P=0.09).CONCLUSION In conclusion,MSCs combined with drugs for treating liver fibrosis effectively make up for the shortcomings of MSCs in their therapeutic effects.However,due to the different drugs,the treatment mechanism and effect also differ.Therefore,more randomized controlled trials are needed to compare the therapeutic efficacy of different drugs in combination with MSCs,

关 键 词：DRUGS ALONE PARTNER 

分 类 号：R575[医药卫生—消化系统]