Recent advancements in understanding of biological role of homeobox C9 in human cancers  

作　　者：Yong Zhang Jing Li 

机构地区：[1]Department of Clinical Laboratory,The Affiliated Lianyungang Oriental Hospital of Kangda College of Nanjing Medical University,Lianyungang 222042,Jiangsu Province,China [2]Department of Respiratory and Critical Care Medicine,The Affiliated Lianyungang Oriental Hospital of Kangda College of Nanjing Medical University,Lianyungang 222042,Jiangsu Province,China

出　　处：《World Journal of Clinical Oncology》2024年第9期1168-1176,共9页世界临床肿瘤学杂志（英文版）

摘　　要：Homeobox(HOX)C9,a member of the HOX family,is an important transcription factor,and it plays a significant role in various biological processes.This family of genes is highly valued for their essential roles in establishing and maintaining the body axis during embryonic development and adult tissues.Further,HOXC9 plays a central role in neuronal differentiation,angiogenesis,and adipose distribution,which are essential for the development of the nervous system,maturation of tissues and organs,and maintenance of energy balance and metabolic health.Recent research has found that abnormal HOXC9 expression is closely associated with the development and progression of various tumor types.The HOXC9 expression level can be an indicator of tumor prognosis.Therefore,elucidating the association between HOXC9 expression and its regulatory mechanisms and tumorigenesis can provide novel insights on the diagnosis and treatment of patients with cancer.

关 键 词：Homeobox C9 PROLIFERATION INVASION Malignant tumor Molecular mechanism 

分 类 号：R737.9[医药卫生—肿瘤]