Application value of dexmedetomidine in anesthesia for elderly patients undergoing radical colon cancer surgery  

作　　者：Hui-Min Bu Min Zhao Hong-Mei Ma Xiao-Peng Tian 

机构地区：[1]Department of Anesthetic Surgery,Qingdao Haici Hospital Affiliated to Qingdao University(Qingdao Hospital of Traditional Chinese Medicine),Qingdao 266033,Shandong Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2024年第8期2671-2678,共8页世界胃肠外科杂志（英文版）（电子版）

摘　　要：BACKGROUND Colon cancer presents a substantial risk to the well-being of elderly people worldwide.With advancements in medical technology,surgical treatment has become the primary approach for managing colon cancer patients.However,due to age-related physiological changes,especially a decline in cognitive function,older patients are more susceptible to the effects of surgery and anesthesia,increasing the relative risk of postoperative cognitive dysfunction(POCD).There-fore,in the surgical treatment of elderly patients with colon cancer,it is of pa-ramount importance to select an appropriate anesthetic approach to reduce the occurrence of POCD,protect brain function,and improve surgical success rates.METHODS One hundred and seventeen patients with colon cancer who underwent elective surgery under general anesthesia were selected and divided into two groups:A and B.Group A received Dex before anesthesia induction,and B group received an equivalent amount of normal saline.Changes in the mini-mental state exami-nation,regional cerebral oxygen saturation(rSO2),bispectral index,glucose uptake rate(GluER),lactate production rate(LacPR),serum S100βand neuron-specific enolase(NSE),POCD,and adverse anesthesia reactions were compared between the two groups.RESULTS Surgical duration,duration of anesthesia,and intraoperative blood loss were comparable between the two groups(P>0.05).The overall dosage of anesthetic drugs used in group A,including propofol and remifentanil,was significantly lower than that used in group B(P<0.05).Group A exhibited higher rSO2 values at the time of endotracheal intubation,30 min after the start of surgery,and immediately after extubation,higher GluER values and lower LacPR values at the time of endotra-cheal intubation,30 min after the start of surgery,immediately after extubation,and 5 min after extubation(P<0.05).Group A exhibited lower levels of serum S100βand NSE 24 h postoperatively and a lower incidence of cognitive dysfunction on the 1st and 5th postoperative days(P<0.05).CONCLUSION The

关 键 词：Colon cancer DEXMEDETOMIDINE General anesthesia ELDERLY Radical colon cancer surgery Bispectral index Cognitive function Regional cerebral oxygen saturation 

分 类 号：R735.2[医药卫生—肿瘤]