Diagnostic value of serum vascular endothelial growth factor and interleukin-17 in primary hepatocellular carcinoma  

作　　者：Qi Tian Hui Zeng Qi-Quan Lu Hai-Ying Xie Yong Li 

机构地区：[1]Clinical Laboratory,Hanyang Hospital Affiliated to Wuhan University of Science and Technology/Wuhan Hanyang Hospital,Wuhan 430050,Hubei Province,China [2]Clinical Laboratory,Wuhan Seventh Hospital,Wuhan 430071,Hubei Province,China [3]Department of Oncology Hematology,Hanyang Hospital Affiliated to Wuhan University of Science and Technology,Wuhan 430050,Hubei Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2024年第9期2934-2941,共8页世界胃肠外科杂志（英文版）（电子版）

摘　　要：BACKGROUND Despite significant advancements in the medical treatment of primary hepato-cellular carcinoma(PHC)in recent years,enhancing therapeutic effects and im-proving prognosis remain substantial challenges worldwide.AIM To investigate the expression levels of serum vascular endothelial growth factor(VEGF)and interleukin(IL)-17 in patients with PHC and evaluate their diagnostic value while exploring their relationship with patients’clinical characteristics.METHODS The study included 50 patients with confirmed PHC who visited Wuhan Han-yang Hospital from January 2021 to January 2022,and 50 healthy individuals from the same period served as the control group.Serum VEGF and IL-17 levels in both groups were measured by Enzyme-Linked Immunosorbent Assay,and their diagnostic value was assessed using receiver operating characteristic(ROC)curves.Pearson correlation analysis was performed to examine the relationship between serum VEGF and IL-17 levels.Pathological data of the PHC patients were analyzed to determine the relationship between serum VEGF and IL-17 levels and pathological characteristics.RESULTS Serum VEGF and IL-17 levels were significantly higher in the study group com-pared to the control group(P<0.05).No significant association was observed between serum VEGF and IL-17 levels and gender,age,combined cirrhosis,tumor diameter,or degree of differentiation(P>0.05).However,there was a significant relationship between clinical TNM stage,tumor metastasis,and serum VEGF and IL-17 levels(P<0.05).Correlation analysis revealed a positive correlation between serum VEGF and IL-17(P<0.05).ROC analysis demonstrated that both serum VEGF and IL-17 had good diagnostic efficacy for PHC.CONCLUSION Serum VEGF and IL-17 levels were significantly higher in PHC patients compared to healthy individuals.Their levels were closely related to pathological features such as tumor metastasis and clinical TNM stage,and there was a significant positive correlation between VEGF and IL-17.These biomarkers may serve as valuable referenc

关 键 词：Primary liver cancer Vascular endothelial growth factor INTERLEUKIN-17 Serum level Diagnostic value Cor-relation 

分 类 号：R735.7[医药卫生—肿瘤]