Overview on signal transduction cascades regulation roles of garlic and its bioactive constituents  

作　　者：Ammad Ahmad Farooqi Iqra Mobeen Rukset Attar Khalida I.Noel Baojun Xu William C.Cho 

机构地区：[1]Institute of Biomedical and Genetic Engineering(IBGE),Islamabad 44000,Pakistan [2]Khursheed Rasheed Hospital Lahore,Lahore 53720,Pakistan [3]Department of Obstetrics and Gynecology,Yeditepe University,Ataşehir 34755,Turkey [4]Human Anatomy Department,College of Medicine,Al-Mustansiriyah University,Baghdad 10036,Iraq [5]Food Science and Technology Program,Department of Life Sciences,BNU-HKBU United International College,Zhuhai 519087,China [6]Department of Clinical Oncology,Queen Elizabeth Hospital,Hong Kong G514TF,China

出　　处：《Food Science and Human Wellness》2024年第5期2353-2362,共10页食品科学与人类健康（英文）

基　　金：funded by a grant(UICR202107)from BNUHKBU United International College.

摘　　要：High-throughput technologies in combination with modern exciting advancements in mass spectrometry-based proteomics and data analysis pipelines have empowered comprehensive characterization of disease phenotypes and their mechanistic regulation by dietary agents and bioactive molecules at unprecedented dimensionality and resolution.Extra-ordinary breakthroughs in the field of nutrigenomics have leveraged our understanding altogether to a new level of maturity.Interdisciplinary researchers have extensively analyzed health promoting and pharmacologically significant properties of garlic(Allium sativum).Importantly,garlic and its biologically active chemicals targeted oncogenic signaling cascades.In this mini-review we have attempted to summarize how garlic and its bioactive constituents regulated signal transduction cascades in cell culture studies and tumor-bearing mice.

关 键 词：Cancer NUTRIGENOMICS SIGNALING Apoptosis Allium sativum 

分 类 号：TS201.2[轻工技术与工程—食品科学]