Molecular mechanisms of aflatoxin neurotoxicity and potential neuroprotective agents  

作　　者：Chongshan Dai Erjie Tian Hui Li Subhajit Das Gupta Zhihui Hao Zhanhui Wang Tony Velkov Jianzhong Shen 

机构地区：[1]National Key Laboratory of Veterinary Public Health and Safety,Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety,College of Veterinary Medicine,China Agricultural University,Beijing 100193,China [2]Guangdong Laboratory for Lingnan Modern Agriculture,Guangzhou 510642,China [3]College of Animal Science and Technology,Henan University of Science and Technology,Luoyang 471023,China [4]Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning,Beijing Center for Disease Prevention and Control,Beijing 100013,China [5]Department of Internal Medicine,University of Texas Southwestern Medical Center,Dallas 75230,USA [6]Monash Biomedicine Discovery Institute,Department of Pharmacology,Monash University,Victoria 3800,Australia

出　　处：《Food Science and Human Wellness》2024年第5期2445-2455,共11页食品科学与人类健康（英文）

基　　金：funded by the Laboratory of Lingnan Modern Agriculture Project(NT2021006);the National Natural Science Foundation of China(32102724);Pinduoduo-China Agricultural University Research Fund(PC2023A01002).

摘　　要：Aflatoxins(AFTs)represent one of the most notorious classes of deadly mycotoxins produced by certain fungi that are found on agricultural crops.Aflatoxins are highly toxic to mammals and are known to cause a series of detrimental effects,including neuro-,hepato-,nephron-,and immuno-toxicity.In this original review we summarize the mechanisms of aflatoxin-induced neurotoxicity and the clinical potential of novel neuroprotective agents.Aflatoxin B1(AFB1)is the most toxic congener among the 21 identified AFTs.Recent studies have shown that food borne exposure to AFB1 and/or its metabolites often leads to fatal neurotoxicity in animals and humans.Animal studies indicated that AFB1 exposure could induce abnormal behavioral changes,including anxiety,lethargy disorders,depression-like behavior,cognitive,learning and memory defects,and decreased feeding behavior.Mechanistically,AFB1 exposure has been associated with lipid peroxidation,ablation of non-enzymatic and enzymatic antioxidant defense systems and decreased neurotransmitter levels.AFB1 exposure has also been shown to induce DNA damage,apoptosis,pyroptosis,and mitochondrial dysfunction in the brain tissue.Several signaling pathways,including gasdermin D,toll like receptor 2(TLR2),TLR4,Akt,NF-κB,ERK/MAPK,protein kinase C(PKC),and mitochondrial apoptotic pathways have been shown to participate in AFB1-induced neuronal or astrocyte cell death.Targeting these pathways by small molecules(e.g.,quercetin,curcumin,and gallic acid,and dimethyl fumarate),Chinese herbal extracts(e.g.,Artichoke leaf extract,Chelidonium majus ethanolic extract,pumpkin extract,and Crocus sativus L.tea),and probiotic supplements could effectively improve AFB1-induced neurobehavioral abnormalities and neurotoxicity.To date,the precise molecular mechanisms of AFB1-induced neurotoxicity and potential neuroprotective agents remain unclear.In the present review,the clinical manifestations,molecular mechanisms,and potential neuroprotective agents of AFB1-induced neurotoxicity are summarized in the br

关 键 词：Aflatoxin B1(AFB1) NEUROTOXICITY Molecular mechanisms Chemical preventions 

分 类 号：TS201.6[轻工技术与工程—食品科学] R99[轻工技术与工程—食品科学与工程]