Capsaicin alleviates the hepatic clock gene disruption and gut microbiota dysbiosis in circadian rhythm disorder mouse model  

作　　者：Bolin Lin Chi-Tang Ho Yawen Wang Jie Xiao Muwen Lu 

机构地区：[1]Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods,College of Food Science,South China Agricultural University,Guangzhou 510642,China [2]Department of Food Science,Rutgers University,New Brunswick 08901,USA [3]Department of Hematology,The Hospital Affiliated to Qingdao University,Qingdao 266000,China

出　　处：《Food Science and Human Wellness》2024年第5期2947-2958,共12页食品科学与人类健康（英文）

基　　金：supported by the Program for Guangdong Introducing Innovative and Entrepreneurial Teams(2019ZT08N291);the Science and Technology Program of Guangzhou,China(2023A04J0760);the Guangdong Basic and Applied Basic Research Foundation(2024A1515030058).

摘　　要：As the body’s internal clock,the circadian rhythm regulates the energy expenditure,appetite,and sleep.There exists a close relationship between the host circadian rhythm and gut microbiota.In this work,a circadian disorder mouse model induced by constant darkness(CD)was constructed to investigate the regulating effects of capsaicin(CAP)on disturbances of metabolism homeostasis and gut microbiota in the respect of circadian rhythm-related mechanisms.Our results indicated that CAP reduced weight gain induced by circadian rhythm disorder in mice by inhibiting fat accumulation in liver and adipose tissue.The rhythmic expressions of circadian clock genes and lipid-metabolism related genes in liver were also recovered by CAP.Microbial study using 16S rRNA sequencing revealed that CAP modulated the gut microbiota richness,diversity and composition,and restored diurnal oscillations of gut microbes at the phylum and family level.These results indicated that CAP could alleviate CD-induced hepatic clock gene disruption and gut microbiota dysbiosis in mice,providing theoretical basis for CAP to be used as a muti-functional ingredient with great healthpromoting effects.

关 键 词：CAPSAICIN Circadian rhythm Hepatic clock gene Gut microbiota Lipid dysregulation 

分 类 号：TS201.4[轻工技术与工程—食品科学]