Exploring the impact of tacrolimus on kidney transplant recipients:insights into immunological outcomes  

作　　者：Zainab A Abbood Ahmed Hamza AL-Shammari Eman M.Jasim Amjad I.Oraibi 

机构地区：[1]Department of Pharmacy,Kut University College,Alkut,Wasit,Iraq,52001 [2]AL-Manara College For Medical Science/Department of Pharmacy,Misan,Iraq,62001

出　　处：《Journal of Chinese Pharmaceutical Sciences》2024年第8期737-750,共14页中国药学（英文版）

摘　　要：To minimize graft rejection,it is crucial to reduce immunosuppression.In the present study,we investigated immunological markers in the blood of transplant patients who did not receive tacrolimus.We also assessed alloreactive CD4+CD25+FoxP3+ Tregs both before transplantation and after tacrolimus reduction.The comparative analysis included 50 individuals experiencing early rejection after tacrolimus discontinuation and 100 non-rejectors.Before reducing tacrolimus,rejectors exhibited elevated levels of memory CD8+T cells compared to Tregs,while non-rejectors displayed a lower ratio of memory CD4+T cells to Tregs.Following tacrolimus removal,rejectors showed an increase in naïve T cells and a decrease in effector T cells.After transplantation,CD4+Treg levels declined,but their anti-donor regulatory function remained consistent in both rejectors and non-rejectors.Immunological correlation revealed an association between acute rejection after tacrolimus discontinuation and the pre-reduction ratio of memory T cells to regulatory T cells.These indicators identified individuals whose immunosuppression could be safely reduced.

关 键 词：TACROLIMUS KIDNEY TRANSPLANT Immune system REJECTION 

分 类 号：R979.5[医药卫生—药品]