玉米、荞麦复配粉对高脂血症大鼠的降血脂作用  

Hypolipidemic Effect of Maize and Buckwheat Complex Powder in Hyperlipidemic Rats

作　　者：刘殊凡 迟晓星[1,2] 王鹤霖 代安娜[1] 李萌 张东杰 LIU Shufan;CHI Xiaoxing;WANG Helin;DAI Anna;LI Meng;ZHANG Dongjie(Food College,Heilongjiang Bayi Agricultural University,Daqing 163319,China;.Coarse Cereals Engineering Research Center,Key Laboratory of Agro-Products Processing and Quality Safety of Heilongjiang Province,Heilongjiang Bayi Agricultural University,Daqing 163319,China)

机构地区：[1]黑龙江八一农垦大学食品学院,黑龙江大庆163319 [2]黑龙江八一农垦大学国家杂粮工程技术研究中心,黑龙江大庆163319

出　　处：《食品工业科技》2024年第19期337-345,共9页Science and Technology of Food Industry

基　　金：黑龙江省自然科学基金项目(LH2021H055)。

摘　　要：为研究玉米荞麦复配粉对高脂血症大鼠脂质代谢的调节作用,将60只大鼠随机分为空白对照组、高脂模型组、阳性组、玉米组、荞麦组、玉米荞麦复配粉组,干预4周,称量大鼠体重、脏器重,测定脂质水平、肝损伤水平及抗氧化水平,并进行肝脏病理组织学检查。结果表明:与高脂模型组相比,玉米荞麦复配粉组能够显著降低血清总胆固醇(Total cholesterol,TC)(1.8 mmol/L)、甘油三酯(Triglyceride,TG)(1.38 mmol/L)、低密度脂蛋白胆固醇(Low density lipoprotein cholesterol,LDL-C)(0.62 mmol/L)的含量,回调高密度脂蛋白胆固醇(High-density lipoprotein cholesterol,HDL-C)(1.27 mmol/L)的含量(P<0.05);玉米、荞麦、玉米荞麦复配粉各组的丙氨酸转氨酶(Alanine transaminase,ALT)、天冬氨酸转氨酶(Aspartate aminotransferase,AST)活力有不同程度降低,其中玉米荞麦复配粉组活力降低效果显著。同时,玉米荞麦复配粉上调了血清中总超氧化物歧化酶(Total superoxide dismutase,SOD)、谷胱甘肽过氧化物酶(Glutathione peroxidase,GSH-Px)的酶活力,下调了血清中丙二醛(Malondialdehyde,MDA)、胆固醇酯(Cholesteryl ester,CHE)的含量,肝脏中亦出现此趋势。肝脏HE染色表明,玉米、荞麦、玉米荞麦复配粉组肝细胞的分布较整齐,大泡性脂滴减少,其中,玉米荞麦复配粉组的改善效果最为显著。由此可见,玉米荞麦复配粉能显著调节高血脂饮食大鼠脂代谢水平,提高肝脏抗氧化能力,修复肝损伤。To explore the effect of corn and buckwheat complex on the regulation of lipid metabolism in hyperlipidemic rats,60 rats were randomly divided into blank control group,hyperlipidemic model group,positive group,corn group,buckwheat group,and corn-buckwheat complex powder group.The intervention was carried out for 4 weeks.The rats and their organs were weighed.Lipid levels,liver injury levels and antioxidant levels were measured,and histologic examination of liver pathology was performed.The results showed that compared to model group,corn-buckwheat complex powder was able to lower the levels of TC(1.8 mmol/L),TG(1.38 mmol/L),LDL-C(0.62 mmol/L),and regress the levels of HDL-C(1.27 mmol/L)significantly(P<0.05).In addition,the ALT and AST activity in these groups had experienced varying degrees of reduction,with the corn-buckwheat complex powder group decreased significantly.Concurrently,the serum of the corn-buckwheat complex powder groups exhibited increased activities of the total SOD and GSH-Px,while the serum levels of MDA and CHE were decreased,a pattern that was also observed in the liver.The results of HE staining indicated that the liver hepatocytes in the corn,buckwheat,and corn-buckwheat complex powder groups were more evenly distributed and had less big vesicular lipid droplets.The corn-buckwheat complex powder group showed the greatest improvement.The research indicated that corn-buckwheat complex powder can significantly regulate the level of lipid metabolism in rats on a high blood lipid diet,and improve the antioxidant capacity of the liver and repair liver damage.

关 键 词：玉米荞麦复配粉 脂质代谢 肝损伤 高脂血症 抗氧化 

分 类 号：TS210.1[轻工技术与工程—粮食、油脂及植物蛋白工程]