合成生物学与纳米生物学的交叉融合及其在肿瘤细菌疗法中的应用进展  

Integration of synthetic biology and nanobiotechnology for the application of bacterial cancer therapy

作　　者：宋健 袁志君 邹丽 冯贻蕊 李晓岩 张佳艺 于晓丽 Song Jian;SONG Jian;YUAN Zhi-Jun;ZOU Li;FENG Yi-Rui;LI Xiao-Yan;ZHANG Jia-Yi;YU Xiao-Li(School of Public Health,Shandong Second Medical University,Weifang 261053,China)

机构地区：[1]山东第二医科大学公共卫生学院,潍坊261053

出　　处：《生命科学》2024年第8期1040-1048,共9页Chinese Bulletin of Life Sciences

基　　金：山东省自然科学基金青年项目(ZR2021QC079)。

摘　　要：肿瘤细菌疗法已有多年历史,但是生物安全性和肿瘤靶向性较低,进而导致治疗效果不理想。近年来,合成生物学和纳米生物学的发展赋予了肿瘤细菌疗法新的希望。合成基因线路有助于实现细菌结构重塑,降低毒性和增强靶向性,纳米技术则可助力基因线路递送,参与介导基因调控,两者的交叉融合可以构建出纳米级功能模块和纳米人工杂合系统,增强改造后体系的功能,有助于解决肿瘤细菌疗法面临的难题,推动临床转化。本文将着重介绍近期合成生物学和纳米生物学交叉融合及其在肿瘤细菌疗法中的研究进展,从合成生物学推动肿瘤细菌疗法的发展、合成生物学与纳米生物学的交叉融合、合成生物学与纳米生物学的交叉融合应用于肿瘤细菌疗法这三个角度,着重阐述该领域近期的研究工作,剖析并展望相关技术在肿瘤细菌疗法中的应用和前景。Bacterial cancer therapy has a long history,but the biosafety and tumor targeting are relatively low,which leads to unsatisfactory therapeutic effects.In recent years,the development of synthetic biology and nanobiotechnology has given new hope to bacterial cancer therapy.Synthetic gene circuits helps to reshape bacterial structures,reduce toxicity and enhance targeting,while nanotechnology can facilitate gene delivery and participate in mediating gene regulation.The integration of synthetic biology and nanobiotechnology can construct nano-scale functional modules and nano-artificial hybrid system,and enhance the function of the modified system.It will help to solve the problems of bacterial cancer therapy and promote clinical transformation.In this review,we focus on the recent research progress in the integration of synthetic biology and nanobiotechnology and their application in bacterial cancer therapy.Three aspects are included:the promotion of synthetic biology in the development of tumor bacterial therapy,the integration of synthetic biology and nanobiotechnology,and the application of such integration in tumor bacterial therapy.Furthermore,the recent research work in this field is discussed,and the application and prospect of related technologies in bacterial cancer therapy are analyzed and prospected.

关 键 词：合成生物学 纳米技术 肿瘤细菌疗法 基因工程 

分 类 号：Q81[生物学—生物工程] R730.5[医药卫生—肿瘤]