胃癌患者血浆胃促生长素浓度对术后并发症及营养状况的预测价值  

Plasma ghrelin concentration on postoperative complications and nutritional status in patients with gastric cancer

作　　者：李炜康 段开鹏 李东宝[1] 任嘉裕 孙小童 顾力行 周进[1] Li Weikang;Duan Kaipeng;Li Dongbao;Ren Jiayu;Sun Xiaotong;Gu Lixing;Zhou Jin(Department of General Surgery,the First Affiliated Hospital of Soochow University,Suzhou 215006,China)

机构地区：[1]苏州大学附属第一医院普通外科,苏州215006

出　　处：《中华普通外科杂志》2024年第8期615-619,共5页Chinese Journal of General Surgery

基　　金：国家自然科学基金(81871952,82372887);江苏省自然科学基金(BK20221242);苏州市第五批姑苏卫生人才培养项目(GSWS2019008);江苏高校“青蓝工程”项目、苏州市临床重点病种诊疗技术专项项目(LCZX202202);苏州大学苏州医学院“临床医学高峰项目”、苏州大学附属第一医院“博习优才铸造计划”领军人才项目、苏州市“科教兴卫”青年科技项目(KJXW2023005);苏州大学附属第一医院博习培育计划项目(BXQN2023027)。

摘　　要：目的探讨胃癌患者神经内分泌功能对术后并发症及营养状况的影响。方法回顾性分析2021年8月至2022年6月在苏州大学第一附属医院普外科接受胃癌根治术的102例胃癌患者的临床资料。结果102例胃癌患者中,18例(17.6%)发生了术后并发症。单因素分析结果显示年龄、BMI、术前血浆胃促生长素浓度、术前血红蛋白量与胃癌根治术后早期并发症有关。多因素分析结果显示年龄、BMI、术前血浆胃促生长素浓度是胃癌患者术后并发症发生的独立危险因素(P<0.05)。胃促生长素浓度的差异性分析显示胃促生长素浓度和患者血红蛋白量、骨骼肌指数(SMI)、白蛋白和肌酐相关,且和SMI呈正相关。结论胃癌患者术前神经内分泌激素胃促生长素浓度降低是术后并发症的独立危险因素,胃促生长素浓度与胃癌患者的SMI相关。ObjectiveTo investigate the impact of neuroendocrine function on postoperative complications and nutritional status in gastric cancer patients.MethodsClinical data of 102 gastric cancer patients who underwent radical gastrectomy at the Department of General Surgery,First Affiliated Hospital of Soochow University,from Aug 2021 to Jun 2022 were retrospectively analyzed.ResultsAmong the 102 gastric cancer patients,18(17.6%)suffered from postoperative complications.Univariate analysis indicated that age,BMI,preoperative plasma ghrelin concentration,and preoperative hemoglobin levels were associated with early postoperative complications following radical gastrectomy.Multivariate analysis revealed that age,BMI,and preoperative plasma ghrelin concentration(P<0.05)were independent risk factors for postoperative complications in gastric cancer patients.Differential analysis of ghrelin concentration demonstrated correlations with hemoglobin levels,skeletal muscle index,albumin,and creatinine,and a positive correlation with the skeletal muscle index.ConclusionsReduced preoperative neuroendocrine hormone ghrelin concentration is an independent risk factor for postoperative complications in gastric cancer patients.Ghrelin concentration is correlated with the skeletal muscle index in these patients.

关 键 词：胃肿瘤 营养评价 胃促生长素 手术后并发症 

分 类 号：R735.2[医药卫生—肿瘤]