质谱在化学小分子创新药发现阶段的应用  

Application of Mass Spectrometry in the Discovery Stage of Innovative Small Molecular Chemical Drugs

作　　者：李玉函 李佳茹 刘保民 Li Yuhan;Li Jiaru;Liu Baomin(Chia Tai Tianqing Pharmaceutical Group Co.,Ltd.,Nanjing 211100,China)

机构地区：[1]正大天晴药业集团股份有限公司,江苏南京211100

出　　处：《广东化工》2024年第18期167-169,共3页Guangdong Chemical Industry

摘　　要：质谱作为一种快速、灵敏、准确地检测物质成分的分析技术,在化学小分子创新药发现阶段发挥着非常重要的作用。应用范围包括合成反应监控、目标分子的结构确证、有关物质鉴定、异构体检测、残留溶剂检测、金属杂质检测、体内外药代动力学、理化参数的测定以及CYP450酶抑制等。本文综述了各种质谱技术在化学小分子创新药发现阶段的各种应用,可为药物分析化学家搭建关键的分析技术平台提供参考。As an analytical technology for rapid,sensitive and accurate detection of material components,mass spectrometry plays an intensely significant role in the discovery stage of innovative small molecule chemical drugs.The scope of application includes synthesis reaction monitoring,the structure confirmation of target molecules,identification of related substances,isomer detection,residual solvent detection,metal impurity detection,in vivo and in vitro pharmacokinetics,determination of physical and chemical parameters,and CYP450 enzyme inhibition.This article reviews the various applications of various mass spectrometry technologies in the discovery stage of chemical small molecule innovative drugs,which can provide a reference for pharmaceutical analytical chemists to establish a key analysis technology platform.

关 键 词：质谱 反应监控 残留溶剂 异构体 药代动力学 CYP450酶抑制率 

分 类 号：TQ460.72[医药卫生—药物分析学]