Bacterial persisters: molecular mechanisms and therapeutic development  

作　　者：Hongxia Niu Jiaying Gu Ying Zhang 

机构地区：[1]School of Basic Medical Science and Key Laboratory of Blood-stasis-toxin Syndrome of Zhejiang Province,Zhejiang Chinese Medical University,Hangzhou 310053 Zhejiang,China [2]State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases,The First Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310003 Zhejiang,China [3]Jinan Microecological Biomedicine Shandong Laboratory,Jinan 250022 Shandong,China

出　　处：《Signal Transduction and Targeted Therapy》2024年第8期3305-3336,共32页信号转导与靶向治疗（英文）

基　　金：We acknowledge the support by Zhejiang Provincial Natural Science Foundation of China(LY24H290004);National Natural Science Foundation of China Youth Foundation(81701969);Natural Science Youth Exploration Program(2022JKZKTS03);Open fund for the State Key Laboratory of Pathogenic Biology of Animal Diseases(SKLVEB2021KFKT002)for HXN;National Center for Infectious Disease startup fund(B2022011-1);Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(No.2021R01012);Jinan Microecological Biomedicine Shandong Laboratory project(UNL-2022050B)for YZ.

摘　　要：Persisters refer to genetically drug susceptible quiescent(non-growing or slow growing)bacteria that survive in stress environments such as antibiotic exposure,acidic and starvation conditions.These cells can regrow after stress removal and remain susceptible to the same stress.Persisters are underlying the problems of treating chronic and persistent infections and relapse infections after treatment,drug resistance development,and biofilm infections,and pose significant challenges for effective treatments.Understanding the characteristics and the exact mechanisms of persister formation,especially the key molecules that affect the formation and survival of the persisters is critical to more effective treatment of chronic and persistent infections.Currently,genes related to persister formation and survival are being discovered and confirmed,but the mechanisms by which bacteria form persisters are very complex,and there are still many unanswered questions.This article comprehensively summarizes the historical background of bacterial persisters,details their complex characteristics and their relationship with antibiotic tolerant and resistant bacteria,systematically elucidates the interplay between various bacterial biological processes and the formation of persister cells,as well as consolidates the diverse anti-persister compounds and treatments.We hope to provide theoretical background for in-depth research on mechanisms of persisters and suggest new ideas for choosing strategies for more effective treatmentofpersistent infections.

关 键 词：MECHANISMS TREATMENT persist 

分 类 号：R37[医药卫生—病原生物学]