Permissive role of CTCF–Hoxb7a–Cdkn2a/b axis in the emergence of hematopoietic stem and progenitor cells during zebrafish embryogenesis  

作　　者：Wenjuan Zhang Xiaofen Liu Wenzhi Xue Lei Gao Dantong Li Changbin Jing Jian Zhao Weijun Pan 

机构地区：[1]State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai 200237,China [2]CAS Key Laboratory of Nutrition,Metabolism and Food Safety,Shanghai Institute of Nutrition and Health(SINH),University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai 200031,China

出　　处：《Journal of Genetics and Genomics》2024年第9期974-977,共4页遗传学报（英文版）

基　　金：supported by the National Key R&D Program of China(2018YFA0800203);the National Natural Science Foundation of China(Distinguished Young Scholars 31925014,Key Program 32130033;General Program 31571505);the Key Research Program of Frontier Sciences,Chinese。

摘　　要：Hematopoietic stem and progenitor cells(HsPCs)are a subset population of multi-potent cells with self-renewal capability and differentiation into all lineages of blood cells(Zhang and Liu,2024).HSPCs arise from the ventral wall of embryonic dorsal aorta,the hemogenic endothelium in the aorta-gonad-mesonephros(AGM)region,tightly controlled by epigenetic,transcriptional,and signaling networks(Wu and Hirschi,2021).However,how developmental hemogenic endothelium performs cell fate surveillances during HSPC emergence and efficiently eliminates them to avoid abnormal hematopoiesisremainselusive.

关 键 词：CTCF eliminate HEMATOPOIETIC 

分 类 号：Q952[生物学—动物学]